The Synthetic Routes of ISOQUINOLINE-8-CARBOXYLIC ACID

The synthesis of ISOQUINOLINE-8-CARBOXYLIC ACID is a challenging task in the chemical industry, and various synthetic routes have been developed over the years to produce this important chemical compound.

One of the most popular synthetic routes is the Williamson ether synthesis, which involves treating an alcohol with an aqueous solution of sodium hydroxide and then adding a halogen such as iodine or bromine to result in the formation of an ether.
This ether can then be treated with a carboxylating agent such as carbon dioxide or a carboxylic acid to form the carboxylic acid.

Another popular synthetic route involves the use of the hydrolysis of an aromatic nitrile, which involves treating a nitrile with sodium hydroxide in the presence of water to result in the formation of an amide.
This amide can then be treated with a carboxylic acid to form the carboxylic acid.

A third synthetic route involves the use of the Bamford-Stevens reaction, which involves the treatment of a ketone or aldehyde with an aqueous solution of sodium hydroxide and then adding a halogen such as chlorine or bromine to result in the formation of a quinone.
This quinone can then be treated with a solution of potassium cyanide and a base such as sodium hydroxide to result in the formation of the carboxylic acid.

Each of these synthetic routes has its own advantages and disadvantages, and the choice of route will depend on the specific requirements of the application.
The Williamson ether synthesis is a mild and versatile synthetic route that can be used to produce a wide range of carboxylic acids, but it may not be suitable for all compounds.
The Bamford-Stevens reaction is a useful synthetic route for compounds with a ketone or aldehyde moiety, but it can be more difficult to perform and may require specialized equipment.

Overall, the synthesis of ISOQUINOLINE-8-CARBOXYLIC ACID is a challenging task in the chemical industry that requires careful consideration of the available synthetic routes and the specific requirements of the application.
With the right synthetic strategy and appropriate equipment, however, this important chemical compound can be synthesized with high yield and purity.