The Synthetic Routes of ISOQUINOLINE-3-CARBOXYLIC ACID HYDRATE

Introduction:
ISOQUINOLINE-3-CARBOXYLIC ACID HYDRATE is an important research chemical that has a wide range of applications in the pharmaceutical and chemical industries.
It is a versatile compound that can be synthesized through several methods, each with its advantages and disadvantages.
In this article, we will discuss the synthetic routes of ISOQUINOLINE-3-CARBOXYLIC ACID HYDRATE and their applications in the chemical industry.

Chemical structure of ISOQUINOLINE-3-CARBOXYLIC ACID HYDRATE:
ISOQUINOLINE-3-CARBOXYLIC ACID HYDRATE is a crystalline hydrate that is commonly used as a pharmaceutical intermediate and a building block for the synthesis of various organic compounds.
The chemical structure of ISOQUINOLINE-3-CARBOXYLIC ACID HYDRATE is shown below:

Synthetic routes for ISOQUINOLINE-3-CARBOXYLIC ACID HYDRATE:
There are several synthetic routes for the preparation of ISOQUINOLINE-3-CARBOXYLIC ACID HYDRATE, including the following:

1. Hydrolysis of N-(2,6-dimethylphenyl)-N'-[(2S)-2-(4-methylphenyl)-2-(4-methyl-2H-1,2,4-triazepin-3-yl)-acetamido]urea: This route involves the hydrolysis of the urea intermediate using a strong acid, such as hydrochloric acid, to liberate the carboxylic acid.
   This method is simple and efficient, but requires the handling of toxic acids.
   
2. Decarboxylation of N-(2,6-dimethylphenyl)-N'-[(2S)-2-(4-methylphenyl)-2-(4-methyl-2H-1,2,4-triazepin-3-yl)acetamide]: This route involves the decarboxylation of the N-(2,6-dimethylphenyl)-N'-[(2S)-2-(4-methylphenyl)-2-(4-methyl-2H-1,2,4-triazepin-3-yl)acetamide] using a strong acid, such as phenyl isocyanate, in the presence of a polar protic solvent, such as ethanol.
   This method is efficient, but requires careful handling of the reagents.
   
3. Decarboxylation of N-(2,6-dimethylphenyl)-N'-[(2S)-2-(4-methylphenyl)-2-(4-methyl-2H-1,2,4-triazepin-3-yl)acetamide] followed by hydrolysis of the resulting amide: This route involves the decarboxylation of the N-(2,6-dimethylphenyl)-N'-[(2S)-2-(4-methylphenyl)-2-(4-methyl-2H-1,2,4-triazepin-3-yl)acetamide] using a strong acid, such as phenyl isocyanate, in the presence of a polar protic solvent, such as ethanol, followed by hydrolysis of the resulting amide using a strong acid, such as hydrochloric acid.
   This method is efficient and simple, but requires the handling of toxic acids.
   

Advantages and disadvantages of the synthetic routes:
Each of the synthetic routes for ISOQUINOLINE-3-CARBOXYLIC ACID HYDRATE has its own advantages and disadvantages.
For example, the hydrolysis of N-(2,6-dimethylphenyl)-N'-[(2S)-2-(4-