The Synthetic Routes of (isoquinolin-7-yloxy)-acetic acid

(Isoquinolin-7-yloxy)-acetic acid is an important intermediate in the production of various pharmaceuticals and agrochemicals.
It is also used as a research chemical in laboratory experimentation.
The synthesis of this compound can be achieved through various routes, some of which are outlined below.

1. The first step in the synthesis of (isoquinolin-7-yloxy)-acetic acid is the synthesis of isoquinoline ring.
   This can be achieved by following the procedure outlined in the literature for the synthesis of isoquinoline ring using isatin as a starting material.
   
2. Once the isoquinoline ring is synthesized, it is treated with a suitable electrophile, such as chloroform, in the presence of a catalyst, such as DMF, to introduce the yloxy group.
   
3. After the introduction of the yloxy group, the compound is treated with acetic anhydride to introduce the acetoxy group.
   
4. The final step in the synthesis of (isoquinolin-7-yloxy)-acetic acid is the removal of the protecting groups.
   This can be achieved using hydrogenation or treatment with a suitable reducing agent.
   

It is important to note that these are just general procedures and may require further optimization depending on the specific reaction conditions and starting materials used.

Another synthetic route for (isoquinolin-7-yloxy)-acetic acid can be through the use of a modified Williamson ether synthesis.
This route involves the treatment of isoquinoline with an alkyl halide in the presence of a polar protic solvent, such as water, and a metal hydroxide catalyst, such as sodium hydroxide.
The reaction is then completed by hydrolysis of the ether with an aqueous acid.

It is also possible to synthesize (isoquinolin-7-yloxy)-acetic acid by a condensation reaction between isoquinoline and acetoxyacetic ester.
This route involves the reaction of isoquinoline with acetoxyacetic ester in the presence of a catalyst, such as pyridine, to form the desired product.

In conclusion, (isoquinolin-7-yloxy)-acetic acid can be synthesized by several routes, including the use of electrophiles, Williamson ether synthesis, and condensation reactions.
The specific route chosen may depend on the availability and cost of starting materials and the desired yield and purity of the product.
It is important to follow proper safety protocols and to handle chemicals in a well-ventilated area to avoid any accidents or injuries.