The Synthetic Routes of IMatinib Para-diaMinoMethylbenzene

IMatinib Para-diaMinoMethylbenzene is an important chemical compound that is used in various applications in the chemical industry.
Synthetic routes for the preparation of this compound have been developed over the years, and several methods are available in the literature.
In this article, we will discuss some of the synthetic routes that are commonly used in the chemical industry to prepare IMatinib Para-diaMinoMethylbenzene.

The first synthetic route that we will discuss is the classical route, which involves the reduction of 4-chloro-2-nitroaniline using hydride reducing agents such as lithium aluminum hydride (LiAlH4).
The reduction of 4-chloro-2-nitroaniline results in the formation of 4-aminonitrobenzene, which is then treated with a para-substituted aniline, such as 4-fluoraniline.
The reaction between the two compounds results in the formation of IMatinib Para-diaMinoMethylbenzene.
This route is relatively simple and straightforward, but it requires the handling of hazardous reagents such as LiAlH4, which can be dangerous if proper safety precautions are not taken.

Another synthetic route that can be used to prepare IMatinib Para-diaMinoMethylbenzene involves the use of a phosphine-mediated coupling reaction.
In this route, 4-fluoraniline is treated with bis(2-oxo-3-oxazolidinyl)phosphine (BOP) and triphenylphosphine (PPh3) in the presence of a base such as potassium carbonate.
The reaction between the reagents results in the formation of a diazo compound, which is then treated with a para-substituted aniline, such as 4-chloraniline.
The reaction between the two compounds results in the formation of IMatinib Para-diaMinoMethylbenzene.
This route is less hazardous than the classical route since it does not involve the use of LiAlH4, but it requires the use of more costly reagents such as PPh3 and BOP.

A third synthetic route that can be used to prepare IMatinib Para-diaMinoMethylbenzene involves the use of a Suzuki coupling reaction.
In this route, a boronic acid derivative of 4-fluoraniline is synthesized and treated with a boronic acid derivative of para-substituted aniline, such as 4-chloraniline.
The reaction between the two compounds results in the formation of IMatinib Para-diaMinoMethylbenzene.
This route is popular due to its ease of execution, high yield, and the fact that it does not involve the use of hazardous reagents.

In conclusion, there are several synthetic routes that can be used to prepare IMatinib Para-diaMinoMethylbenzene, and the choice of route depends on the specific needs and requirements of the chemical industry.
The classical route is relatively simple and straightforward, while the phosphine-mediated and Suzuki coupling routes are less hazardous and more efficient.
Regardless of the route chosen, it is important to follow proper safety precautions and to use the appropriate reagents and equipment to ensure the safe and efficient preparation of IMatinib Para-diaMinoMethylbenzene.