The Synthetic Routes of Hexahydro-1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinyl]-1H-azepine

The synthesis of Hexahydro-1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinyl]-1H-azepine is a complex and multi-step process that requires the use of various chemical reagents and techniques.
The synthesis of this compound is a significant achievement in the field of organic chemistry and has potential applications in various areas of the chemical industry.

Step 1: Synthesis of N-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-Yl)Pyrimidine-2,4-Diamine
The first step in the synthesis of Hexahydro-1-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinyl]-1H-azepine is the synthesis of N-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-Yl)Pyrimidine-2,4-Diamine.
This compound is synthesized by a combination of chemical reactions such as N-BO bond formation, oxidative carboxylation, and ring-closing metathesis polymerization.

Step 2: Synthesis of 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-5-Sulfonyl Chloride
In this step, 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-5-Sulfonyl Chloride is synthesized by subjecting N-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)Pyrimidine-2,4-Diamine to sulfonylation using sulfur trioxide and chlorosulfonic acid.

Step 3: Synthesis of 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-5-Carboxylic Acid
In this step, 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-5-Sulfonyl Chloride is treated with sodium hydroxide to remove the sulfuric acid group, and then subjected to decarboxylation to yield 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-5-Carboxylic Acid.

Step 4: Synthesis of 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Pyrimidin-2-Yl)Pyrimidine-1,3-Diamide
In this step, 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine-5-Carboxylic Acid is treated with 2-Amino-Pyrimidine-5-Carboxylic Acid Hydrochloride in the presence of a solvent such as N,N-Dimethylacetamide and a catalyst such as Hemptrizine to yield 2-(4,4,5,5-Tetramethyl-