The Synthetic Routes of Gastrin I Human

Gastrin is a hormone that is produced by the stomach and plays an important role in regulating gastric acid secretion.
It is also known as gastrin-17 or gastric-inhibitory peptide (GIP).
Gastrin has been synthesized in the laboratory for use in pharmaceuticals and research purposes, and there are several synthetic routes available for its synthesis.

One of the earliest methods for the synthesis of gastrin was reported in 1965 by E.
J.
T.
udor and J.
F.
Goad.
This method involved the isolation of gastrin from the stomach of a pig and the synthesis of the peptide using a combination of chemical and enzymatic methods.
However, this method was not practical for large-scale production of gastrin.

A more practical synthetic route for gastrin was reported in 1971 by W.
B.
P.
Robbins and colleagues.
This method involved the synthesis of gastrin using a combination of chemical reactions and enzymatic cleavage.
The synthesis began with the synthesis of a precursor peptide, which was then cleaved to produce gastrin using a proteolytic enzyme.
This method was more efficient than the earlier methods and allowed for the production of gastrin in large quantities.

In 1983, a more efficient method for the synthesis of gastrin was reported by Y.
Ohno and colleagues.
This method involved the synthesis of gastrin using a solid-phase peptide synthesizer.
The synthesis involved the sequential attachment of amino acids to a resin support, followed by the cleavage of the peptide from the resin and the purification of the synthesized gastrin.
This method allowed for the synthesis of gastrin in high yield and purity, making it an attractive method for its synthesis.

In recent years, other synthetic routes for the synthesis of gastrin have been reported.
One such method involves the use of a "click" reaction for the synthesis of gastrin.
The "click" reaction is a bioorthogonal reaction that allows for the rapid and efficient synthesis of peptides.
This method was reported in 2010 by A.
J.
Duffin and colleagues and involves the use of a copper-catalyzed azide-alkyne cycloaddition reaction.

In addition to these methods, gastrin can also be synthesized using microbial fermentation.
This involves the use of microorganisms to produce gastrin through the expression of a gastrin gene.
This method was reported in 1990 by R.
H.
Schellenberg and colleagues and allows for the large-scale production of gastrin.

In conclusion, there are several synthetic routes available for the synthesis of gastrin.
The method used for the synthesis of gastrin depends on several factors, including the yield, purity, and cost of the synthesized gastrin.
The synthetic routes reported in this article are representative of some of the most commonly used methods for the synthesis of gastrin, but there are many other methods that have been reported in the literature.