The Synthetic Routes of Furo[2,3-c]pyridin-3(2H)-one

Furo[2,3-c]pyridin-3(2H)-one is an important synthetic intermediate in the chemical industry, with a wide range of applications in the production of pharmaceuticals, agrochemicals, and other chemical products.
There are several synthetic routes available for the synthesis of Furo[2,3-c]pyridin-3(2H)-one, each with its own advantages and disadvantages.

One of the most common synthetic routes for the synthesis of Furo[2,3-c]pyridin-3(2H)-one is the Williamson ether synthesis.
This reaction involves the reaction of a phenol with a concentrated hydrochloric acid in the presence of a base, such as sodium hydroxide.
The resulting product is a mixture of the desired Furo[2,3-c]pyridin-3(2H)-one, as well as other byproducts.
This route is relatively simple and inexpensive, but it has a high yield of byproducts and requires a large amount of wastewater treatment to remove the byproducts.

Another synthetic route for the synthesis of Furo[2,3-c]pyridin-3(2H)-one is the oxidation of a phenol with sodium periodate.
This reaction involves the addition of sodium periodate to a solution of a phenol in a solvent, such as water or ether.
The resulting product is a mixture of the desired Furo[2,3-c]pyridin-3(2H)-one, as well as other byproducts.
This route is relatively simple and efficient, but it requires the use of hazardous reagents and may produce hazardous byproducts that require special handling and disposal.

Yet another synthetic route for the synthesis of Furo[2,3-c]pyridin-3(2H)-one is the P2NP reaction.
This reaction involves the reaction of a primary or secondary amine with a chloroplatinic acid in the presence of a solvent, such as water or ether.
The resulting product is a mixture of the desired Furo[2,3-c]pyridin-3(2H)-one, as well as other byproducts.
This route is relatively efficient and can produce high yields of the desired product, but it requires the use of hazardous reagents and may produce hazardous byproducts that require special handling and disposal.

Overall, the synthetic routes for the synthesis of Furo[2,3-c]pyridin-3(2H)-one vary in terms of their efficiency, safety, and environmental impact.
It is important for chemical manufacturers to carefully consider these factors when selecting a synthetic route for their operations.