The Synthetic Routes of Ethyl-(5-fluoro-pyrimidin-2-yl)-amine

Ethyl-(5-fluoro-pyrimidin-2-yl)-amine is a synthetic chemical compound that is commonly used in various applications in the chemical industry.
It is a derivative of pyrimidine, a compound that is found in many organic compounds and is known for its unique properties.
The synthetic routes to ethyl-(5-fluoro-pyrimidin-2-yl)-amine can vary depending on the desired product and the starting materials used in the reaction.
In this article, we will discuss some of the commonly used synthetic routes to ethyl-(5-fluoro-pyrimidin-2-yl)-amine in the chemical industry.

One of the most common methods for synthesizing ethyl-(5-fluoro-pyrimidin-2-yl)-amine is through the intermediates, 2-fluoro-5-nitro-benzoic acid and ethyl-amine.
This synthesis method involves a series of steps, including the reaction of 2-fluoro-5-nitro-benzoic acid with ethyl-amine, followed by the use of a catalyst, such as hydrochloric acid, to generate the desired product.
This method is commonly used in the chemical industry as it is relatively simple and efficient.

Another common synthetic route to ethyl-(5-fluoro-pyrimidin-2-yl)-amine is through the use of a nitrile intermediate.
This method involves the reaction of 5-fluoro-pyrimidine-2-carbonitrile with ethyl-amine in the presence of a base, such as sodium hydroxide.
This reaction is followed by the removal of the nitrogen oxide group using a reducing agent, such as lithium aluminum hydride, to generate the desired product.
This method is commonly used in the chemical industry as it is relatively mild and efficient, and it does not require the use of harsh reagents.

In addition to the above methods, ethyl-(5-fluoro-pyrimidin-2-yl)-amine can also be synthesized through the use of a Grignard reagent.
This method involves the reaction of 2-fluoro-5-nitro-benzoic acid with magnesium metal in the presence of an organic solvent, such as ether, to generate the Grignard reagent.
This reagent is then treated with ethyl-amine to generate the desired product.
This method is commonly used in the chemical industry as it allows for the efficient use of intermediates and it does not require the use of harsh reagents.

Overall, the synthetic routes to ethyl-(5-fluoro-pyrimidin-2-yl)-amine can vary depending on the desired product and the starting materials used in the reaction.
The methods discussed in this article, including the use of 2-fluoro-5-nitro-benzoic acid and ethyl-amine, the use of a nitrile intermediate, and the use of a Grignard reagent, are all commonly used in the chemical industry for the synthesis of this compound.
The selection of a particular synthetic route will depend on the desired properties of the final product, the availability and cost of the starting materials, and the efficiency of the reaction.