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Ethyl 4-amino-2-(3-pyridinyl)-5-pyrimidinecarboxylate, also known as celecoxib, is a medication used for the treatment of inflammation and pain.
It is primarily used to treat symptoms of osteoarthritis, rheumatoid arthritis, and acute pain.
The compound is synthesized through several synthetic routes, with various methods used in the chemical industry.
The most common synthetic route for the preparation of celecoxib is through the Pegasus reaction.
This reaction involves the formation of a pyrimidine ring, which is a key component of the molecule.
The method requires the use of sodium hydroxide, under conditions that ensure the formation of the desired product.
Another synthetic route for the preparation of celecoxib is through the Ullmann reaction.
This reaction involves the formation of an amide from an acid and a primary amine.
The method is commonly used in the chemical industry for the synthesis of various compounds and is a versatile method for the preparation of celecoxib.
Yet another synthetic route for the preparation of celecoxib is through the Suzuki reaction.
This reaction involves the formation of a carbon-carbon bond between boron and carbon.
The method is commonly used in the chemical industry for the synthesis of various compounds and is a versatile method for the preparation of celecoxib.
Celecoxib can also be synthesized through the Stille reaction, which is a palladium-catalyzed cross-coupling reaction between an aryl halide and an aryl or heteroaryl boronate.
This method is commonly used in the chemical industry for the synthesis of various compounds and is a versatile method for the preparation of celecoxib.
In conclusion, there are several synthetic routes for the preparation of celecoxib, with the most common being the Pegasus reaction, the Ullmann reaction, the Suzuki reaction, and the Stille reaction.
These methods are commonly used in the chemical industry for the synthesis of various compounds, and they offer a range of options for the preparation of celecoxib.
The choice of synthetic route will depend on various factors, including the desired yield, the cost of the reaction, and the availability of the starting materials.
