The Synthetic Routes of (E)-3-[2-(7-Chloro-2-quinolinyl)ethenyl]benzaldehyde

(E)-3-[2-(7-Chloro-2-quinolinyl)ethenyl]benzaldehyde is an important intermediate in the synthesis of various pharmaceuticals and other chemical products.
This aldehyde is used as a building block for the synthesis of numerous compounds that have potential therapeutic applications.
The synthesis of (E)-3-[2-(7-Chloro-2-quinolinyl)ethenyl]benzaldehyde can be accomplished through several different synthetic routes.
In this article, we will discuss two commonly used synthetic routes for the synthesis of (E)-3-[2-(7-Chloro-2-quinolinyl)ethenyl]benzaldehyde.

Route 1: via Knoevenagel Condensation

The first synthetic route for the synthesis of (E)-3-[2-(7-Chloro-2-quinolinyl)ethenyl]benzaldehyde involves a Knoevenagel condensation reaction.
In this route, the starting materials are 2-quinolineethanamine and benzaldehyde.
The reaction is carried out in the presence of a base, such as sodium hydroxide, and is typically performed in aqueous solution.
The reaction proceeds via a series of steps, including the condensation of the starting materials, followed by alkylation and dehydration to form the final product.

Route 2: via Pyrrolidine-Thiourea Synthesis

The second synthetic route for the synthesis of (E)-3-[2-(7-Chloro-2-quinolinyl)ethenyl]benzaldehyde involves a pyrrolidine-thiourea synthesis.
In this route, the starting materials are iodoacetamide and pyrrolidine-2,5-dithiourea.
The reaction is carried out in the presence of a solvent, such as dichloromethane, and is typically performed under conditions that allow for the formation of the final product.
The reaction proceeds via a series of steps, including the condensation of the starting materials, followed by thiourea formation, followed by aldol condensation to form the final product.

Advantages of Synthetic Routes

Both of the synthetic routes described above have their own advantages.
The Knoevenagel condensation route is relatively simple, easy to perform, and is often used to synthesize molecules with similar structures.
The pyrrolidine-thiourea synthesis route allows for the synthesis of molecules with more complex structures, and is often used in the synthesis of pharmaceuticals and other chemical products.

Applications of (E)-3-[2-(7-Chloro-2-quinolinyl)ethenyl]benzaldehyde

(E)-3-[2-(7-Chloro-2-quinolinyl)ethenyl]benzaldehyde is an important intermediate in the synthesis of various pharmaceuticals and other chemical products.
Some of the most notable applications of this aldehyde include its use in the synthesis of antidepressant drugs, antipsychotic drugs, and anti-Alzheimer's disease drugs.
In addition to its use in the pharmaceutical industry, (E)-3-[2-(7-Chloro-2-quinolinyl)ethenyl]benzaldehyde is also used in the production of dyes, fragrances, and other chemical products.

Conclusion

(E)-3-[2-(7-Chloro-2-quinolinyl)ethenyl]benzaldehyde is an important intermediate in the synthesis of various pharmaceuticals and other chemical products.
There are two commonly used synthetic routes for the synthesis of (E)-3-[2-(7-Chloro-2-quinolinyl)ethenyl]benzaldehyde , via Knoevenagel condensation and via Pyrrolidine-Thiourea synthesis.
Both routes have advantages and disadvantages, and the choice of route depends on the desired product and the specific synthetic requirements.
The applications of (E)-3