The Synthetic Routes of DIMETHYL 3,3'-BIPYRIDINE-5,5'-DICARBOXYLATE

Synthetic Route of Dimethyl 3,3'-Bipyrimidine-5,5'-Dicarboxylate: An Overview in the Chemical Industry

Dimethyl 3,3'-bipyrimidine-5,5'-dicarboxylate is an important organic compound that has various applications in the chemical industry.
This compound is widely used as a building block for the synthesis of pharmaceuticals, agrochemicals, and other industrial chemicals.
Due to its importance, there are several synthetic routes available for the production of dimethyl 3,3'-bipyrimidine-5,5'-dicarboxylate.
In this article, we will discuss the different synthetic routes available for the production of this compound and their importance in the chemical industry.

1. The Stickler Route

The Stickler route is one of the most commonly used synthetic routes for the production of dimethyl 3,3'-bipyrimidine-5,5'-dicarboxylate.
In this route, 2,4-diaminopyrimidine is condensed with methyl iodide in the presence of a strong base, such as sodium hydroxide, to form dimethyl 3,3'-bipyrimidine-5,5'-dicarboxylate.
This route is simple and efficient and provides a good yield of the desired product.

1. The Collins Route

The Collins route is another commonly used synthetic route for the production of dimethyl 3,3'-bipyrimidine-5,5'-dicarboxylate.
In this route, a mixture of dimethylformamide and dimethylacetamide is heated with a mixture of 2,4-diaminopyrimidine and hydrazoic acid in the presence of a base, such as sodium hydroxide.
The reaction is then completed by heating the mixture in the presence of a solvent, such as ethanol, to form dimethyl 3,3'-bipyrimidine-5,5'-dicarboxylate.

1. The Nozaki Route

The Nozaki route is another synthetic route used for the production of dimethyl 3,3'-bipyrimidine-5,5'-dicarboxylate.
In this route, a mixture of 2-chloromethyl-4,5-diaminopyrimidine and methyl iodide is heated in the presence of a solvent, such as acetonitrile, and a base, such as sodium hydroxide.
The reaction is then completed by heating the mixture in the presence of a reducing agent, such as lithium aluminum hydride, to form dimethyl 3,3'-bipyrimidine-5,5'-dicarboxylate.

1. The Bedistance Route

The Bedistance route is a synthetic route that uses lithium diisopropyl amide as a base to form dimethyl 3,3'-bipyrimidine-5,5'-dicarboxylate.
In this route, a mixture of 2,4-diaminopyrimidine and methyl iodide is heated in the presence of lithium diisopropyl amide, and the reaction is completed by heating the mixture in the presence of a solvent, such as ethanol.

In conclusion, there are several synthetic routes available for the production of dimethyl 3,3'-bipyrimidine-5,5'-dicarboxylate.
The most commonly used routes are the Stickler and Collins routes.
These routes offer a good yield of the desired product and are simple and efficient.
Each route has its own advantages and disadvantages, and the choice of route depends on the specific needs of the chemical company and the desired product properties.

It is important to note that the