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Di-o-tolylguanidine, commonly abbreviated as DOG, is an important organic compound that is widely used in various industrial applications.
Its synthetic routes have been extensively studied and developed over the years, and there are several methods available for its synthesis.
One of the most common methods for the synthesis of DOG involves the reaction of o-toluidine with formaldehyde in the presence of a Lewis acid catalyst, such as aluminum chloride.
This reaction results in the formation of N-allyl urea, which is then dehydrated to form DOG.
Another route involves the reaction of o-xylidine with formaldehyde in the presence of an acid catalyst, such as sulfuric acid.
This reaction also results in the formation of N-allyl urea, which can then be dehydrated to form DOG.
Another synthetic route for DOG involves the reaction of o-toluidine with chloroform in the presence of a base, such as sodium hydroxide.
This reaction results in the formation of N-chloromethyl o-toluidine, which can then be hydrolyzed to form DOG.
Another method involves the reaction of o-toluidine with thionyl chloride in the presence of a solvent, such as benzene.
This reaction results in the formation of N-chloromethyl o-toluidine, which can then be reduced to form DOG.
In addition to these synthetic routes, there are also several other methods that have been developed for the synthesis of DOG.
These include the use of enzymatic methods, microwave-assisted synthesis, and solid-phase synthesis, among others.
The choice of synthetic route for DOG depends on a variety of factors, including the available starting materials, the desired purity and yield of the product, and the scale of production.
Some synthetic routes may be more practical for small-scale production, while others may be more suitable for large-scale production.
Overall, the synthetic routes for DOG are diverse and have been extensively studied and developed over the years.
This has made it possible to produce DOG in a variety of forms and with a range of properties, making it a valuable material for a wide range of industrial applications.
