The Synthetic Routes of Dasatinib

Dasatinib is a synthetic drug that is used to treat certain types of cancer, including chronic myeloid leukemia and cancer of the stomach and digestive system.
It works by inhibiting the activity of a protein called BCR-ABL, which is produced by a genetic change called the Philadelphia chromosome.
This genetic change is present in some types of leukemia and can cause the production of abnormal white blood cells.

There are several synthetic routes for dasatinib, each of which involves a series of chemical reactions to produce the final product.
One common synthetic route is known as the "Uemori synthesis," which involves a sequence of reactions that starts with a compound called chloroacetyl chloride and ends with the production of dasatinib.

To begin the Uemori synthesis, chloroacetyl chloride is treated with a compound called phenyl isocyanate in the presence of a solvent such as acetonitrile.
This leads to the formation of a compound called phenyl 2-chloroacetamide, which is then treated with a compound called 1,1'-carbonyldiimidazole in the presence of a base such as triethylamine.
This results in the formation of a compound called N-(2-chloroacetamido)-5-methoxycarbonyl-2-nitrobenzene.

Next, the compound is treated with a compound called hydroxylamine in the presence of a solvent such as water, which leads to the formation of a compound called N-(5-methoxycarbonyl-2-nitrobenzene-3-yl)hydroxylamine.
This compound is then treated with a compound called hydrazine in the presence of a solvent such as methanol, which leads to the formation of a compound called N-(5-methoxycarbonyl-2-nitrobenzene-3-yl)methyl hydrazine.

Finally, the compound is treated with a compound called phenyl magnesium bromide in the presence of a solvent such as ether, which leads to the formation of dasatinib.
This synthetic route requires a number of steps and the use of several different chemicals, and the final product must be purified to remove any impurities before it can be used as a drug.

Another synthetic route for dasatinib is known as the "Sørensen synthesis," which involves a different sequence of reactions.
This synthesis begins with the compound called phenyl-A-D-galactopyranoside and ends with the production of dasatinib.

In summary, dasatinib is a synthetic drug that is used to treat certain types of cancer.
It works by inhibiting the activity of a protein called BCR-ABL, which is produced by a genetic change called the Philadelphia chromosome.
There are several synthetic routes for dasatinib, each of which involves a series of chemical reactions to produce the final product.
The Uemori synthesis is one such route, which involves the use of several different chemicals and several steps.
The Sørensen synthesis is another route, which involves a different sequence of reactions and starts with a different compound.
The synthetic routes for dasatinib require advanced chemical knowledge and technology, and the final product must be purified to remove any impurities before it can be used as a drug.