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Bromocriptine mesylate is a widely used drug in the treatment of various medical conditions such as Parkinson's disease, hyperprolactinemia, and tumors of the pituitary gland.
It is a synthetic derivative of ergot, a fungus that grows on grains, and it acts as a dopamine receptor agonist.
The demand for bromocriptine mesylate has been increasing steadily over the years, and as a result, various synthetic routes have been developed to produce it.
One of the most commonly used synthetic routes for producing bromocriptine mesylate is the synthesis of Ergotamine tartrate, which is a precursor to bromocriptine mesylate.
Ergotamine tartrate is synthesized by the condensation of ergoline with a tartaric acid derivative.
The ergoline is then converted to Ergotamine diacetate by a hydrolytic process, and this compound is then hydrogenated to produce Ergotamine tartrate.
The Ergotamine tartrate is then methylated with methyl iodide to produce bromocriptine mesylate.
Another synthetic route for producing bromocriptine mesylate involves the synthesis of tryptamine from fenchyl alcohol, followed by the coupling of tryptamine with a phenylalanine derivative.
The resulting compound is then converted to bromocriptine mesylate through a series of chemical reactions.
Yet another synthetic route for producing bromocriptine mesylate involves the synthesis of 3-methoxy-4-hydroxyphenyl-butyrate from tyrosine, followed by the condensation of this compound with an ethyl bromide to produce 3-ethyl-4-hydroxyphenyl-butyrate.
This compound is then converted to bromocriptine mesylate through a series of chemical reactions.
The choice of synthetic route for producing bromocriptine mesylate depends on a variety of factors such as cost, availability of starting materials, and the desired yield.
In addition, the purity of the final product and the safety of the synthetic route are also important considerations.
Overall, the Synthetic routes of Bromocriptine mesylate are many, and the choice of one route over the other will depend on the factors such as cost, availability of starting materials, and the desired yield.
The final product should meet the standards of purity and safety and should be effective in the treatment of various medical conditions.