The Synthetic Routes of Benzenethiol, 3,4-diamino- (9CI)

Benzenethiol, 3,4-diamino- (9CI) is a versatile synthetic intermediate that is widely used in the chemical industry for the production of a variety of industrial and consumer products.
The synthesis of benzenethiol, 3,4-diamino- (9CI) can be achieved through several different synthetic routes, each with its own advantages and disadvantages.

One of the most common synthetic routes for benzenethiol, 3,4-diamino- (9CI) involves the reaction of benzaldehyde with sodium hydroxide in the presence of an acid catalyst, such as sulfuric acid or hydrochloric acid.
This reaction results in the formation of benzenethiol, 3,4-diamino- (9CI) through the Kolbe-Schmitt reaction.
This route is relatively simple and inexpensive, but it does produce a relatively large amount of hydrogen chloride gas, which can be hazardous.

Another synthetic route for benzenethiol, 3,4-diamino- (9CI) involves the reaction of benzaldehyde with a primary amine, such as methylamine or ethylamine.
This reaction is typically carried out in the presence of an acid catalyst, such as hydrochloric acid or sulfuric acid.
This route is less hazardous than the Kolbe-Schmitt reaction, but it does require the handling of the volatile amine.

A third synthetic route for benzenethiol, 3,4-diamino- (9CI) involves the reaction of benzaldehyde with a secondary amine, such as dimethylamine or diethylamine.
This reaction is typically carried out in the presence of an acid catalyst, such as hydrochloric acid or sulfuric acid.
This route is less hazardous than the Kolbe-Schmitt reaction, and it does not require the handling of volatile amines.

Each of these synthetic routes for benzenethiol, 3,4-diamino- (9CI) has its own advantages and disadvantages, and the choice of route will depend on the specific requirements of the application.
Once the benzenethiol, 3,4-diamino- (9CI) has been synthesized, it can be further purified and transformed into a wide range of industrial and consumer products, including plastics, dyes, pharmaceuticals, and personal care products.