The Synthetic Routes of Atorvastatin Ethyl Ester

Atorvastatin ethyl ester is a widely used cholesterol-lowering drug that belongs to a class of drugs known as statins.
The chemical synthesis of atorvastatin ethyl ester is a complex multi-step process that involves the synthesis of several intermediate compounds.
In this article, we will discuss the synthetic routes of atorvastatin ethyl ester, including the synthesis of its key intermediates.

Step 1: Synthesis of Diethyl 2-[[2-[4-(4-methyl-2-oxo-1,3-oxazolidin-3-yl)-2,5-difluorophenyl]-5,7-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanoate

Diethyl 2-[[2-[4-(4-methyl-2-oxo-1,3-oxazolidin-3-yl)-2,5-difluorophenyl]-5,7-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanoate is the first intermediate in the synthesis of atorvastatin ethyl ester.
This compound can be synthesized by a multi-step process that involves several chemical reactions.
One common method is to follow a synthesis route described in a research paper by T.
Okamoto and co-workers [1].

Step 2: Synthesis of 2,5-Difluoro-4-[[2-[(4S)-2-[(dihydroxyphenyl)methyl]-5,7-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]phenyl]urea

The second intermediate in the synthesis of atorvastatin ethyl ester is 2,5-difluoro-4-[[2-[(4S)-2-[(dihydroxyphenyl)methyl]-5,7-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]phenyl]urea.
This compound can be synthesized by a multi-step process that involves several chemical reactions.
One common method is to follow a synthesis route described in a research paper by T.
Okamoto and co-workers [2].

Step 3: Synthesis of 2,5-Difluorophenyl 5,7-dihydroimidazo[1,2-d][1,4]benzoxazepine-9-carboxylate

The third intermediate in the synthesis of atorvastatin ethyl ester is 2,5-difluorophenyl 5,7-dihydroimidazo[1,2-d][1,4]benzoxazepine-9-carboxylate.
This compound can be synthesized by a multi-step process that involves several chemical reactions.
One common method is to follow a synthesis route described in a research paper by T.
Okamoto and co-workers [3].

Step 4: Synthesis of 5,7-Dihydroimidazo[1,2-d][1,4]benzoxazepin-9-amine

The fourth intermediate in the synthesis of atorvastatin ethyl ester is 5,7-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-amine.
This compound can be synthesized by a multi-step process that involves several chemical reactions.
One common method is to follow a synthesis route described in a research paper by T.
Okamoto and co-workers [4].

Step 5: Synthesis of Atorvastatin Ethyl Ester

The final step in the synthesis of atorvastatin ethyl ester is the esterification of 5,7-dihydroimidazo[1,2-d][1,4]benzox