The Synthetic Routes of Aliskiren inter-11

Aliskiren is an angiotensin-converting enzyme (ACE) inhibitor, which is used to treat hypertension and other cardiovascular diseases.
The synthesis of aliskiren has been extensively studied, and several synthetic routes have been developed to synthesize this compound.
In this article, we will discuss some of the most commonly used synthetic routes for the synthesis of aliskiren.

The first reported synthetic route for aliskiren was a 16-step synthesis developed by the pharmaceutical company, Takeda.
This synthesis involved the condensation of several reagents and the protection and deprotection of various functional groups.
The synthesis was complex and time-consuming, and several modifications have been made to simplify and shorten the synthesis.

Another popular synthetic route for aliskiren involves the use of a Suzuki coupling reaction.
This reaction involves the coupling of two boronic acids, which are then transformed into an intermediate that can be reduced to the final product.
This synthetic route involves fewer steps and is less expensive than the original Takeda synthesis.

Yet another synthetic route for aliskiren involves the use of a microwave-assisted synthesis.
In this synthesis, the reaction components are placed in a microwave reactor, which enables the reaction to proceed at a higher temperature and in a shorter time.
This synthesis is faster and more efficient than traditional synthetic routes and has been used to synthesize other complex organic molecules.

In addition to these synthetic routes, other methods have been developed for the synthesis of aliskiren.
For example, a biotechnological method has been developed that involves the use of genetically modified bacteria to produce the compound.
This method is more environmentally friendly and less expensive than traditional synthetic routes.

Overall, the synthesis of aliskiren has been extensively studied, and several synthetic routes have been developed.
These synthetic routes range from complex and time-consuming methods to faster and more efficient methods.
The choice of synthetic route depends on several factors, including the availability of reagents, the cost of the synthesis, and the desired yield of the product.
The development of new synthetic routes for aliskiren and other pharmaceuticals is an active area of research in the chemical industry, as it has the potential to improve the efficiency and cost-effectiveness of drug production.