The Synthetic Routes of ACETIC ACID 2-CYANO-PYRIDIN-3-YLMETHYL ESTER

The synthesis of 2-cyano-pyridin-3-ylmethyl ester, commonly known as acetic acid 2-cyano-pyridin-3-ylmethyl ester, is an important process in the chemical industry.
The compound is used as an intermediate in the synthesis of various chemicals, including agrochemicals, pharmaceuticals, and dyes.
There are several synthetic routes that can be used to synthesize this compound, each with its own advantages and disadvantages.

One common synthetic route to acetic acid 2-cyano-pyridin-3-ylmethyl ester involves the reaction of 2-cyano-pyridine with methyl acetate in the presence of a Lewis acid catalyst, such as titanium(IV) chloride.
This reaction can be carried out at room temperature, and the product can be easily purified by distillation.
This route is relatively simple and efficient, but it requires the use of hazardous reagents and catalysts, and the purification process can be challenging.

Another synthetic route involves the reaction of 2-cyano-pyridine with methyl iodide in the presence of a base, such as sodium hydroxide.
This reaction can be carried out at elevated temperatures, and the product can be easily purified by dissolving it in a solvent, such as ethyl acetate, and then washing it with water.
This route is less hazardous than the first route, but it requires the use of a base, which can be expensive and hazardous to handle.

A third synthetic route involves the reaction of 2-cyano-pyridine with methyl phenyl sulfonate in the presence of a base, such as sodium hydroxide.
This reaction can be carried out at elevated temperatures, and the product can be easily purified by dissolving it in a solvent, such as ethyl acetate, and then washing it with water.
This route is less hazardous than the first route, but it requires the use of a base, which can be expensive and hazardous to handle.

In conclusion, there are several synthetic routes to acetic acid 2-cyano-pyridin-3-ylmethyl ester, each with its own advantages and disadvantages.
The most appropriate route will depend on the availability and cost of the reagents, the purification process, and the safety considerations.
As with any chemical synthesis, it is important to follow proper safety protocols and to dispose of any hazardous materials in accordance with local regulations.
The synthesis of acetic acid 2-cyano-pyridin-3-ylmethyl ester is an important process in the chemical industry, and there is ongoing research to develop more efficient and cost-effective synthetic routes.