The Synthetic Routes of 952680-40-9

The Synthetic Routes of 952680-40-9: A Critical Analysis in the Chemical Industry

Abstract:

952680-40-9 is a synthetic compound widely used in various industries such as pharmaceuticals, agrochemicals, and electronics.
The chemical structure of 952680-40-9 makes it an important building block for the synthesis of several other chemicals.
The synthetic routes for 952680-40-9 have been well-documented in the scientific literature, with many different methods reported for its synthesis.
In this article, we will critically analyze the different synthetic routes reported for 952680-40-9 and highlight their advantages and disadvantages.

Introduction:

952680-40-9 is a molecule belonging to the aryl amine family.
It is commonly used as a building block for the synthesis of other chemicals.
The use of 952680-40-9 in various industries has led to a significant increase in its demand.
As a result, the synthesis of 952680-40-9 has become a topic of interest in the chemical industry.

Synthetic Routes for 952680-40-9:

There are several methods reported in the literature for the synthesis of 952680-40-9.
Some of the commonly used methods are:

Method 1: via N-Cyanation of Aniline

In this method, aniline is treated with sodium hydroxide and sodium cyanide to form the N-cyanate derivative.
The N-cyanate derivative is then treated with a base to form the N-aminocyanate derivative.
The N-aminocyanate derivative is then reacted with ethyl bromide and sodium hydroxide to form 952680-40-9.

Advantages:

• The method is simple and straightforward.
  
• It uses readily available starting materials.
  

Disadvantages:

• The reaction conditions are quite harsh, making the process costly.
  
• The use of sodium cyanide poses a safety hazard.
  

Method 2: via the Ullmann Condensation

In this method, 4-chloroaniline and formaldehyde are treated with sodium hydroxide to form the Ullmann complex.
The Ullmann complex is then treated with n-propanol to form 952680-40-9.

Advantages:

• The method is relatively mild, using readily available starting materials.
  
• The reaction conditions are not as harsh as the N-cyanation method.
  

Disadvantages:

• The synthesis requires specialized equipment such as a Dean-Stark water separator.
  
• The yield of the process is relatively low.
  

Method 3: via the Stille Cross-Coupling

In this method, 4-chloroaniline and phenylboronic acid are treated with a palladium catalyst to form the Stille adduct.
The Stille adduct is then treated with sodium hydroxide and sodium bicarbonate to form 952680-40-9.

Advantages:

• The method is highly efficient, providing high yield.
  
• The use of a palladium catalyst makes the process environmentally friendly.
  

Disadvantages:

• The reaction conditions are relatively harsh, requiring specialized equipment.
  
• The cost of the process is relatively high.
  

Conclusion:

In conclusion, there are several methods reported in the literature for the synthesis of 952680-40-9.
Each method has its advantages and disadvantages.
The N-