The Synthetic Routes of 7-METHOXY-ISOQUINOLINE

The 7-methoxy-isoquoline is an important compound in the field of medicinal chemistry, as it has been found to have potential therapeutic properties against various diseases such as cancer, Alzheimer's, and malaria.
There are several synthetic routes that can be used to synthesize 7-methoxy-isoquoline, each with its own advantages and disadvantages.
In this article, we will discuss some of the most commonly used synthetic routes for the synthesis of 7-methoxy-isoquoline.

1. The Williamson ether synthesis
   One of the most commonly used methods for the synthesis of 7-methoxy-isoquoline is the Williamson ether synthesis.
   This reaction involves the treatment of an alkyl halide with a strong base, such as sodium hydroxide, in the presence of an alcohol.
   The alcohol used in this reaction is known as the "Williamson's ether," which acts as a nucleophile and attacks the carbon atom next to the halogen.
   The resulting intermediate is then treated with an aqueous solution of sodium carbonate, which decomposes into the desired 7-methoxy-isoquoline.
   
2. The nucleophilic substitution reaction
   Another method for the synthesis of 7-methoxy-isoquoline is the nucleophilic substitution reaction.
   This reaction involves the treatment of an alkyl halide with a nucleophile, such as ethanol or sodium hydroxide, in the presence of a solvent such as water or ethanol.
   The nucleophile attacks the carbon atom next to the halogen, leading to the formation of an intermediate which can undergo further reaction to give 7-methoxy-isoquoline.
   
3. The Grignard reaction
   The Grignard reaction is another common method for the synthesis of 7-methoxy-isoquoline.
   This reaction involves the treatment of an alkyl halide with magnesium metal in the presence of a solvent such as ether or benzene.
   The magnesium metal reacts with the halogen in the alkyl halide to form a Grignard reagent, which is then treated with an aqueous solution of sodium carbonate to give 7-methoxy-isoquoline.
   
4. The reduction of 8-methoxy-quinoline
   8-methoxy-quinoline is a related compound to 7-methoxy-isoquoline, and its reduction can be used to synthesize 7-methoxy-isoquoline.
   This reaction involves the treatment of 8-methoxy-quinoline with a reducing agent, such as lithium aluminum hydride or hydrogen in the presence of a solvent such as ether or hexane.
   The reducing agent attacks the nitrogen atom in the molecule, leading to the formation of an amine intermediate which can then be treated with an aqueous solution of sodium carbonate to give 7-methoxy-isoquoline.
   

In conclusion, there are several synthetic routes for the synthesis of 7-methoxy-isoquoline, each with its own advantages and disadvantages.
The choice of route depends on the availability of starting materials, the desired yield, and the potential cost and environmental impact of the reaction.
Regardless of the chosen route, the synthesis of 7-methoxy-isoquoline is a complex process that requires careful attention to detail and the use of specialized equipment and reagents.