The Synthetic Routes of 7-DEAZAGUANOSINE

7-Deazaguanine is an organic compound with the molecular formula C10H12N4O.
It is a derivative of guanine, which is a naturally occurring purine base found in DNA and RNA.
7-Deazaguanine has been studied for its potential use in cancer treatment and as an antiviral medication.
It is also used in the synthesis of other organic compounds in the chemical industry.

There are several synthetic routes that can be used to produce 7-deazaguanine.
One of the most common methods involves the use of the Amadori rearrangement, which is a chemical reaction that converts a carbonyl group into an amino group.
This reaction is used to synthesize 7-deazaguanine from the precursor substance 7-amino-8-oxo-2H-purin-2-one.

Another synthetic route for 7-deazaguanine involves the use of the Leuckart reaction.
This reaction involves the condensation of an aromatic aldehyde and an amine in the presence of an acid catalyst.
The reaction produces a substituted guanidine, which can be further transformed into 7-deazaguanine through a series of chemical reactions.

7-deazaguanine can also be synthesized through the use of a sequence of organic reactions known as the Passerini reaction and the Bischler-Nuemann reaction.
The Passerini reaction involves the condensation of an aryl or heteroaryl halide with a hydrazine derivative in the presence of a Lewis acid catalyst.
The Bischler-Nuemann reaction is a chemical reaction in which a nitrite is reduced to an amine in the presence of an alkali metal hydroxide.
These reactions can be used to synthesize 7-deazaguanine from the appropriate starting materials.

Once 7-deazaguanine has been synthesized, it can be further transformed into other useful compounds through various chemical reactions.
One such reaction is the transformation of 7-deazaguanine into 7-deaza-2'-deoxyguanosine, which is a useful building block for the synthesis of oligonucleotides.
This transformation can be accomplished through a series of chemical reactions, including a reductive alkylation step and a bromination step.

Another use of 7-deazaguanine is in the synthesis of cytostatic agents.
Cytostatic agents are compounds that inhibit the growth and division of cancer cells.
One example of a cytostatic agent synthesized from 7-deazaguanine is 1,4-dihydropyridine-3,5-dicarboxylate, which has been shown to have cytotoxic and cytostatic activity against cancer cells in vitro.

In conclusion, 7-deazaguanine is an important synthetic building block in the chemical industry.
Its unique structure and chemical properties make it useful in a variety of applications, including the synthesis of pharmaceuticals, oligonucleotides, and cytostatic agents.
The Amadori rearrangement, Leuckart reaction, Passerini reaction, and Bischler-Nuemann reaction are all useful methods for synthesizing 7-deazaguanine.
The transformation of 7-deazaguanine into other useful compounds can be accomplished through a variety of chemical reactions, making it a versatile building block in the synthesis of a wide range of organic compounds.