The Synthetic Routes of 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one

7,8-difluorodibenzo[b,e]thiepin-11(6H)-one is a synthetic compound that has a wide range of applications in the chemical industry.
It is commonly used as a building block for the synthesis of other organic compounds, and it has been found to have anti-inflammatory, anti-tumor, and antiviral properties.
In this article, we will discuss the synthetic routes of 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one, which can be broadly classified into three categories, namely: (1) traditional synthesis routes, (2) modern synthesis routes, and (3) green synthesis routes.

Traditional Synthesis Routes

The traditional synthesis routes of 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one involved the use of several steps and reagents.
One of the most common traditional synthesis routes involved the reaction of 7,8-difluorodibenzofuran with acetic anhydride in the presence of an organic solvent such as acetonitrile.
The reaction resulted in the formation of the acetyl derivative of 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one, which was then reduced using hydrogenation catalysts such as palladium on barium oxide to obtain the final product.

Modern Synthesis Routes

In recent years, several modern synthesis routes for 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one have been developed, which involve the use of more efficient and cost-effective methods.
One such route involves the reaction of 7,8-difluorodibenzothiophene with chloroform in the presence of a Lewis acid catalyst such as aluminum chloride.
The resulting product is then treated with a reducing agent such as lithium aluminum hydride to obtain the final product.

Another modern synthesis route involves the use of microwave irradiation.
In this method, 7,8-difluorodibenzofuran is irradiated with microwaves in the presence of a polar solvent such as acetonitrile and a base such as sodium hydroxide.
The resulting product is then hydrolyzed using a strong acid such as hydrochloric acid to obtain the final product.

Green Synthesis Routes

In recent years, there has been a growing interest in developing green synthesis routes for 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one, which involve the use of eco-friendly reagents and solvents.
One such route involves the use of aqueous hydrogen peroxide as the oxidizing agent for the synthesis of 7,8-difluorodibenzofuran, which is then reduced using sodium borohydride to obtain the final product.

Another green synthesis route involves the use of microwave-assisted hydrothermal synthesis.
In this method, 7,8-difluorodibenzothiophene and a palladium catalyst are reacted in the presence of a polar solvent such as ethanol and a base such as sodium hydroxide under microwave irradiation.
The resulting product is then reduced using a reducing agent such as ascorbic acid to obtain the final product.

Conclusion

In conclusion, 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one is a versatile synthetic compound that has a wide range of applications in the chemical industry.
There are several traditional, modern, and green synthesis routes available for the synthesis of this compound, each with its own advantages and disadvantages.
The choice of synthesis route depends on several factors