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6-Methyl-5-propyl-4(1H)-pyrimidinone, also known as uracil, is an important intermediate in the synthesis of several pharmaceuticals, agrochemicals, and other chemicals.
The demand for uracil has been growing steadily in recent years, and as a result, various synthetic routes to this compound have been developed in the chemical industry.
In this article, we will discuss some of the most commonly used synthetic routes for the synthesis of 6-methyl-5-propyl-4(1H)-pyrimidinone.
- Hydrolysis of N-Boc-6-methyl-5-propyl-4(1H)-pyrimidinone
N-Boc-6-methyl-5-propyl-4(1H)-pyrimidinone can be hydrolyzed using a strong acid, such as hydrochloric acid, to produce uracil.
The reaction is usually carried out in the presence of a solvent, such as ethyl acetate, and the resulting uracil can be purified using a suitable method, such as column chromatography or recrystallization.
- Reduction of N-Boc-6-methyl-5-propyl-4(1H)-pyrimidinone with Lithium Aluminum Hydride (LAH)
N-Boc-6-methyl-5-propyl-4(1H)-pyrimidinone can be reduced using lithium aluminum hydride (LAH) to produce uracil.
The reaction is usually carried out in the presence of a solvent, such as ether, and the resulting uracil can be purified using a suitable method, such as column chromatography or recrystallization.
- Nitrite Reduction of N-Boc-6-methyl-5-propyl-4(1H)-pyrimidinone
N-Boc-6-methyl-5-propyl-4(1H)-pyrimidinone can be reduced using nitrite to produce uracil.
The reaction is usually carried out in the presence of a solvent, such as acetonitrile, and the resulting uracil can be purified using a suitable method, such as column chromatography or recrystallization.
- Reduction of N-Boc-6-methyl-5-propyl-4(1H)-pyrimidinone with Hydrazine
N-Boc-6-methyl-5-propyl-4(1H)-pyrimidinone can be reduced using hydrazine to produce uracil.
The reaction is usually carried out in the presence of a solvent, such as ethanol, and the resulting uracil can be purified using a suitable method, such as column chromatography or recrystallization.
- Reduction of N-Boc-6-methyl-5-propyl-4(1H)-pyrimidinone with Diisobutylaluminum Hydride (DIBAL-H)
N-Boc-6-methyl-5-propyl-4(1H)-pyrimidinone can be reduced using diisobutylaluminum hydride (DIBAL-H) to produce uracil.
The reaction is usually carried out in the presence of a solvent, such as toluene, and the resulting uracil can be purified using a suitable method, such as column chromatography or recrystallization.
In conclusion, the synthetic routes for 6-methyl-5-propyl-4(1H)-pyrimidinone, such as those described above, are important in the chemical industry for the synthesis of various pharma
