The Synthetic Routes of 6-METHYL-2-PHENYL-4(1H)PYRIMIDINONE

The synthetic routes of 6-methyl-2-phenyl-4(1H)pyrimidinone, also known as Methylphenamid, are an essential part of the chemical industry.
This compound is used in various applications, including as a pharmaceutical intermediate, electrolyte for lithium batteries, and as a building block for the synthesis of other organic compounds.

One of the most commonly used synthetic routes for the production of 6-methyl-2-phenyl-4(1H)pyrimidinone involves the reaction of 2-chloro-6-methyl-4(1H)pyrimidinone with α-phenyl-α-methylstyrene in the presence of a Lewis acid catalyst such as aluminum chloride.
This reaction leads to the formation of the desired compound, along with the corresponding hydrochloric acid salt.

Another synthetic route involves the reaction of 2-nitro-6-methyl-4(1H)pyrimidinone with benzaldehyde in the presence of sodium hydroxide and sodium cyanide.
This reaction results in the synthesis of the desired compound, along with the corresponding sodium nitrate byproduct.

In addition to these synthetic routes, 6-methyl-2-phenyl-4(1H)pyrimidinone can also be synthesized via a multi-step synthesis process that involves the condensation of various starting materials.
This process typically involves the use of reagents such as hydrochloric acid, acetic acid, and sodium nitrate, and results in the synthesis of the desired compound in a multi-step process.

The choice of synthetic route for the production of 6-methyl-2-phenyl-4(1H)pyrimidinone depends on a variety of factors, including the desired yield, purity, and cost of the final product.
Each synthetic route has its own advantages and disadvantages, and the selection of the appropriate route depends on the specific requirements of the application.

Overall, the synthetic routes of 6-methyl-2-phenyl-4(1H)pyrimidinone are essential to the chemical industry, as this compound is widely used in a variety of applications.
These routes involve the use of various reagents and catalysts, and the selection of the appropriate route depends on the specific requirements of the application.