The Synthetic Routes of 6-Isoquinolinecarboxaldehyde (9CI)

Synthetic routes of 6-Isoquinolinecarboxaldehyde (9CI) in the Chemical Industry: An Overview

6-Isoquinolinecarboxaldehyde, commonly abbreviated as 9CI, is a versatile chemical compound that finds widespread use in various industries, including the chemical, pharmaceutical, and agrochemical industries.
The high demand for this compound has led to the development of several synthetic routes for its production.
In this article, we will discuss some of the most commonly used synthetic routes for the production of 9CI.

1. Grignard Reagent Synthesis

One of the most commonly used methods for the synthesis of 9CI is the Grignard reagent synthesis.
In this process, a magnesium halide is treated with a primary or secondary alcohol to form a Grignard reagent.
The Grignard reagent is then treated with an aqueous solution of a carboxylic acid to form the 9CI compound.
This process is highly reproducible and results in a high yield of the desired product.

2. Hydrolysis of Nitrile

Another commonly used synthetic route involves the hydrolysis of a nitrile.
In this process, a nitrile is treated with water and a strong acid to form the 9CI compound.
This process is simple, cost-effective, and can be easily scaled up for commercial production.

3. Leuckart's Reagent Synthesis

Leuckart's reagent is another commonly used reagent for the synthesis of 9CI.
In this process, a sodium or potassium hydroxide solution is treated with a solution of a phenyl isocyanate in an alcohol solvent.
The resulting Leuckart's reagent is then treated with an aqueous solution of a carboxylic acid to form the 9CI compound.
This process is highly efficient and provides a high yield of the desired product.

4. Nitrosonium Ion Synthesis

The nitrosonium ion synthesis is another method used for the production of 9CI.
In this process, a nitrosonium ion in the presence of a Lewis acid is treated with a primary or secondary alcohol to form the 9CI compound.
This process is highly efficient and provides a high yield of the desired product.

5. Direct halogenation

In this process, a compound is directly halogenated by treatment with a halogenating agent such as chlorine or bromine.
The resulting compound is then treated with a reducing agent to convert it to the 9CI compound.

6. Reduction of a nitro or diazo compound

In this process, a nitro or diazo compound is reduced to form the 9CI compound.
This process is commonly used in the production of agrochemicals and pharmaceuticals.

7. Other synthetic routes

Other synthetic routes for the production of 9CI include the use of olefins, hydrazides, and amides among others.
These methods have varying degrees of efficiency and are used depending on the specific requirements of the application.

Conclusion

In conclusion, the production of 6-Isoquinolinecarboxaldehyde (9CI) is a complex process that involves several synthetic routes.
The choice of the synthetic route used depends on the specific requirements of the application, such as cost, yield, and purity of the desired product.
The Grignard reagent synthesis, hydrolysis of nitrile, Leuckart's reagent synthesis, nitrosonium ion synthesis, direct halogenation, reduction of a nitro or diazo compound, and other synthetic routes are some of the commonly used methods for the production of 9CI.
The development of new and more efficient synthetic routes for the production of 9CI is an ongoing process, driven by the increasing demand for this versatile compound in