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6-Chloro-5-nitroquinoline is a synthetic compound that has a wide range of applications in the chemical industry.
It is commonly used as a reagent in organic synthesis, as a catalyst in chemical reactions, and as a preservative in various products.
The synthetic routes of 6-chloro-5-nitroquinoline can be broadly classified into two categories: classical and modern.
Classical Synthetic Routes of 6-Chloro-5-Nitroquinoline:
The classical synthetic routes of 6-chloro-5-nitroquinoline involve the use of traditional synthesis methods, such as the Williamson reaction, the Barbour method, and the electrophilic substitution reaction.
The Williamson reaction involves the reduction of chloranilic acid to form aniline, which is then treated with a strong base to form 6-chloro-5-nitroquinoline.
The Barbour method involves the reduction of chloranilic acid with sodium in the presence of benzene to form 6-chloro-5-nitroquinoline.
The electrophilic substitution reaction involves the substitution of functional groups in aniline with chlorine, which results in the formation of 6-chloro-5-nitroquinoline.
Modern Synthetic Routes of 6-Chloro-5-Nitroquinoline:
The modern synthetic routes of 6-chloro-5-nitroquinoline involve the use of more efficient and environmentally friendly synthesis methods, such as the nitration of aniline, the diazotization of aniline, and the hydrolysis of chloranilic acid.
The nitration of aniline involves the treatment of aniline with nitric acid to form 6-chloro-5-nitroquinoline.
The diazotization of aniline involves the treatment of aniline with nitrous acid to form a diazonium salt, which is then treated with a base to form 6-chloro-5-nitroquinoline.
The hydrolysis of chloranilic acid involves the treatment of chloranilic acid with water to form 6-chloro-5-nitroquinoline.
Advantages of Modern Synthetic Routes:
The modern synthetic routes of 6-chloro-5-nitroquinoline have several advantages over the classical synthetic routes.
The modern routes are more efficient and cost-effective, as they require less time and resources to synthesize the compound.
The modern routes also have a lower environmental impact, as they generate less waste and use fewer hazardous chemicals.
Additionally, the modern routes provide a higher yield of the desired product, which means that less material is needed to produce the desired quantity of 6-chloro-5-nitroquinoline.
Applications of 6-Chloro-5-Nitroquinoline:
6-chloro-5-nitroquinoline has a wide range of applications in the chemical industry.
It is commonly used as a reagent in organic synthesis, as a catalyst in chemical reactions, and as a preservative in various products.
In organic synthesis, 6-chloro-5-nitroquinoline is used as a intermediate for the synthesis of other organic compounds.
In chemical reactions, 6-chloro-5-nitroquinoline is used as a catalyst to speed up the reaction rate and improve the yield of the desired product.
As a preservative, 6-chloro-5-nitroquinoline is used to prevent the growth of microorganisms in various products, such as pharmaceuticals, cosmetics, and food products.
Conclusion:
The synthetic routes of 6-chloro-5-nitroquinoline are an important aspect of the chemical industry, as they provide a means of synthes