The Synthetic Routes of (6-Chloro-2-methanesulfonyl-pyrimidin-4-yl)-ethyl-amine

The synthesis of novel chemicals is a crucial aspect of the chemical industry.
In particular, the synthesis of (6-chloro-2-methanesulfonyl-pyrimidin-4-yl)-ethyl-amine, a compound with potential medicinal properties, has been the subject of much research in recent years.
There are several synthetic routes available for the preparation of this compound, each with its own advantages and disadvantages.
In this article, we will discuss some of the most commonly used synthetic routes for the synthesis of (6-chloro-2-methanesulfonyl-pyrimidin-4-yl)-ethyl-amine, highlighting their respective strengths and weaknesses.

Route 1: via N-Bromosuccinimide (NBS)

One of the most common methods for the synthesis of (6-chloro-2-methanesulfonyl-pyrimidin-4-yl)-ethyl-amine is through the use of N-bromosuccinimide (NBS).
This route involves the reaction of (6-chloro-2-methyl-pyrimidin-4-yl)-ethyl-amine with NBS in the presence of a solvent such as dichloromethane or chloroform.
The reaction is typically carried out at room temperature and is often complete within a few hours.

The advantages of this route include its simplicity and the availability of the starting materials.
Additionally, NBS is relatively inexpensive and easy to handle, making this route a cost-effective option for the synthesis of (6-chloro-2-methanesulfonyl-pyrimidin-4-yl)-ethyl-amine.

However, there are also some disadvantages to this route.
NBS is a strong oxidizing agent and can often lead to unwanted side reactions, such as the oxidation of the amine group.
This can result in a lower yield of the desired product and may require additional purification steps to remove impurities.

Route 2: via Hydrazine

Another synthetic route for the synthesis of (6-chloro-2-methanesulfonyl-pyrimidin-4-yl)-ethyl-amine involves the use of hydrazine.
This route involves the reaction of (6-chloro-2-methyl-pyrimidin-4-yl)-ethyl-amine with hydrazine in the presence of a solvent such as ethanol or water.
The reaction is typically carried out at elevated temperatures, such as 60-70°C, and is often complete within a few hours.

The advantages of this route include its mild reaction conditions, which can lead to less unwanted side reactions compared to the NBS route.
Additionally, hydrazine is relatively inexpensive and easy to handle, making this route a cost-effective option for the synthesis of (6-chloro-2-methanesulfonyl-pyrimidin-4-yl)-ethyl-amine.

However, there are also some disadvantages to this route.
Hydrazine can be highly toxic and must be handled with caution.
Additionally, the reaction can often result in a mixture of products, requiring additional purification steps to obtain the desired compound.

Route 3: via Chlorosulfonic Acid

A third synthetic route for the synthesis of (6-chloro-2-methanesulfonyl-pyrimidin-4-yl)-ethyl-amine involves the use of chlorosulfonic acid.
This route involves the reaction of (6-chloro-2-methyl-pyrimidin-4-yl)-ethyl-amine with chlorosulfonic acid in the presence of a solvent such as chloroform or carbon tetrachloride.
The reaction is typically carried