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The synthesis of (6-chloro-2-methanesulfinyl-pyrimidin-4-yl)-ethyl-amine, also known as MET-08298147, is a complex and multi-step process that involves various chemical reactions and purification steps.
The final product is an important intermediate in the synthesis of certain pharmaceuticals, agrochemicals, and other chemical products.
One of the most common synthetic routes for MET-08298147 involves the reaction of 2-chloro-6-methanesulfenamide with ethyl amine in the presence of a strong base, such as sodium hydroxide.
This reaction forms the basis of the synthesis of the sulfenamide group, which is a common building block in the synthesis of many organic compounds.
The next step in the synthesis of MET-08298147 involves the reduction of the sulfenamide group to form the corresponding amide.
This is achieved using a reducing agent, such as lithium aluminum hydride (LiAlH4), in the presence of a solvent, such as dichloromethane.
The reduction step is important because it reduces the oxidation state of the sulfur atom, which is crucial for the subsequent steps in the synthesis.
After the reduction step, the amide is transformed into an alkylating agent, which is used to introduce the required substituents onto the pyrimidine ring.
This step involves the reaction of the amide with a reactive alkylating agent, such as iodomethane, in the presence of a catalyst, such as dimethylsulfate.
The resulting compound is then hydrolyzed using a strong acid, such as hydrochloric acid, to produce the final product.
Another synthetic route for MET-08298147 involves the reaction of 2-chloro-6-methanesulfenamide with ethyl bromide in the presence of a base, such as sodium hydroxide.
This reaction forms the basis of the synthesis of the sulfenamide group, which is a common building block in the synthesis of many organic compounds.
The next step in the synthesis of MET-08298147 involves the reduction of the sulfenamide group to form the corresponding amide.
This is achieved using a reducing agent, such as lithium aluminum hydride (LiAlH4), in the presence of a solvent, such as dichloromethane.
The reduction step is important because it reduces the oxidation state of the sulfur atom, which is crucial for the subsequent steps in the synthesis.
After the reduction step, the amide is transformed into an alkylating agent, which is used to introduce the required substituents onto the pyrimidine ring.
This step involves the reaction of the amide with a reactive alkylating agent, such as iodomethane, in the presence of a catalyst, such as dimethylsulfate.
The resulting compound is then hydrolyzed using a strong acid, such as hydrochloric acid, to produce the final product.
In conclusion, the synthesis of MET-08298147 is a complex multi-step process that involves various chemical reactions and purification steps.
The final product is an important intermediate in the synthesis of certain pharmaceuticals, agrochemicals, and other chemical products.
The different synthetic routes available for the synthesis of MET-08298147 involve variations in the reaction conditions, reagents, and intermediate products, but ultimately lead to the same final product.
These synthetic routes are important for the large-scale production of MET-08298147 and its derivatives, as they provide a reliable and efficient means of producing this important intermediate.
