The Synthetic Routes of 6-CHLORO-2-HYDROXYQUINOLINE

The synthesis of 6-chloro-2-hydroxyquinoline, commonly referred to as 6-chloroquine, is a critical step in the production of various chemicals and pharmaceutical products.
As a versatile compound with broad applications, 6-chloroquine can be synthesized through various methods, each with its own advantages and disadvantages.
In this article, we will discuss the most commonly used synthetic routes for the production of 6-chloro-2-hydroxyquinoline.

1. The classic synthesis route of 6-chloro-2-hydroxyquinoline uses the reaction of chloroform with 2,3-dichloro-5,6-dihydroxybenzene, which is then treated with sodium hydroxide.
   This route is relatively simple and cost-effective, but it involves the use of toxic and flammable reagents.
   
2. Another route for the synthesis of 6-chloro-2-hydroxyquinoline is the reaction of 2,3-dichloro-5,6-dihydroxybenzene with chloroform and carbon tetrachloride in the presence of a mineral acid catalyst.
   This route is more efficient than the classic method and is less hazardous to handle.
   
3. An alternative synthesis route for 6-chloro-2-hydroxyquinoline involves the reaction of 2,3-dichloro-5,6-dihydroxybenzene with chloroacetic acid in the presence of a strong inorganic base, such as sodium hydroxide.
   This method is safer to handle than the classic route and is more efficient.
   
4. 6-chloro-2-hydroxyquinoline can also be synthesized through the reaction of 2,3-dichloro-5,6-dihydroxybenzene with 2,2,2-trichloroacetamide in the presence of a strong acid catalyst, such as sulfuric acid.
   This route is more efficient and can be easily scaled up.
   

In conclusion, 6-chloro-2-hydroxyquinoline is a versatile compound with many applications in the chemical industry.
The synthesis of 6-chloro-2-hydroxyquinoline can be achieved through various routes, each with its own advantages and disadvantages.
It is important to consider the hazards and risks associated with each synthesis route and to choose the most appropriate method for a particular application.
As the demand for 6-chloro-2-hydroxyquinoline continues to grow, it is likely that new and more efficient synthesis methods will be developed to meet this demand.