The Synthetic Routes of 6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine

The 6-chloro-2,3-diphenylimidazo[1,2-b]pyridazine is an important synthetic intermediate used in various chemical reactions.
It has been widely studied by organic chemists due to its unique structural properties, which make it amenable to a variety of synthetic routes.

One of the most commonly used methods for the synthesis of 6-chloro-2,3-diphenylimidazo[1,2-b]pyridazine is the reaction of 2,3-diphenylmaleimide with chloramine-T in the presence of a solvent like acetonitrile or dichloromethane.
The reaction of 2,3-diphenylmaleimide with chloramine-T in the presence of a base like sodium hydroxide or potassium hydroxide has also been reported in the literature.

Another route for the synthesis of 6-chloro-2,3-diphenylimidazo[1,2-b]pyridazine is through the reaction of 2,3-diphenyl(2H)-imidazo[1,2-d][1,4]benzoxazepin-9-one with chloroform in the presence of a base like sodium hydroxide or potassium hydroxide.
The reaction proceeds through an intermediate imidazole, which is formed by the reaction between the imidazo[1,2-d][1,4]benzoxazepin-9-one and chloroform.

Another synthetic route to 6-chloro-2,3-diphenylimidazo[1,2-b]pyridazine involves the reaction of 2,3-diphenyl(2H)-imidazo[1,2-f][1,4]benzoxazepin-8-one with chloroform in the presence of a base like sodium hydroxide or potassium hydroxide.
This reaction also proceeds through an intermediate imidazole, which is formed by the reaction between the imidazo[1,2-f][1,4]benzoxazepin-8-one and chloroform.

In addition to these methods, other routes have been reported in the literature, such as the reaction of 2,3-diphenyl(2H)-imidazo[1,2-e][1,4]benzoxazepin-7-one with chloroform in the presence of a base like sodium hydroxide or potassium hydroxide, and the reaction of 2,3-diphenyl(2H)-imidazo[1,2-b]pyridine-2,6-dione with chloroform in the presence of a base like sodium hydroxide or potassium hydroxide.

Overall, the synthesis of 6-chloro-2,3-diphenylimidazo[1,2-b]pyridazine can be accomplished through a variety of methods, and the choice of route will depend on the specific needs of the synthetic protocol.
The reaction of 2,3-diphenylmaleimide with chloramine-T in the presence of a solvent like acetonitrile or dichloromethane is a commonly used method, but other routes, such as the reaction of 2,3-diphenyl(2H)-imidazo[1,2-d][1,4]benzoxazepin-9-one with chloroform in the presence of a base like sodium hydroxide or potassium hydroxide, have also been reported.
The reaction proceeds through an intermediate imidazole, which is formed by the reaction between the imidazo[1,2-d][1,4]benzoxazepin-9-one and chloroform.