The Synthetic Routes of 5-Pyrimidinecarboxylic acid, 4-ethyl-2-methyl- (9CI)

The 5-pyrimidinecarboxylic acid, 4-ethyl-2-methyl- (9CI) is an important organic compound that is widely used in the chemical industry.
It is mainly used as an intermediate in the production of various chemicals, pharmaceuticals, and agrochemicals.
The synthetic routes of 5-pyrimidinecarboxylic acid, 4-ethyl-2-methyl- (9CI) can be broadly classified into three categories: direct synthesis, indirect synthesis, and semisynthesis.

Direct synthesis is the most common method for the production of 5-pyrimidinecarboxylic acid, 4-ethyl-2-methyl- (9CI).
This method involves the reaction of 4-ethyl-2-methyl-5-pyrimidinecarboxylic acid (4E)-2-methyl-5-pyrimidinecarboxylic acid with an appropriate reagent.
One of the most commonly used methods is the reaction of 4E)-2-methyl-5-pyrimidinecarboxylic acid with chloroformic acid in the presence of a solvent such as dichloromethane.
The reaction results in the formation of 5-pyrimidinecarboxylic acid, 4-ethyl-2-methyl- (9CI) along with the formation of a benzaldehyde byproduct.

Indirect synthesis is another method for the production of 5-pyrimidinecarboxylic acid, 4-ethyl-2-methyl- (9CI).
This method involves the synthesis of the intermediate compound 4E)-2-methyl-5-pyrimidinecarboxylic acid, followed by its further reaction with an appropriate reagent to yield the final product.
One of the most commonly used methods is the reaction of (4E)-2-methyl-5-pyrimidinecarboxylic acid with an appropriate reagent such as 4-nitrophenyl chloride in the presence of a solvent such as DMF.
The reaction results in the formation of 5-pyrimidinecarboxylic acid, 4-ethyl-2-methyl- (9CI) along with the formation of a ammonium sulfate byproduct.

Semisynthesis is a method that is used in the production of 5-pyrimidinecarboxylic acid, 4-ethyl-2-methyl- (9CI) that involves the synthesis of the intermediate compound (4E)-2-methyl-5-pyrimidinecarboxylic acid, followed by its further reaction with an appropriate reagent to yield the final product.
One of the most commonly used methods is the reaction of (4E)-2-methyl-5-pyrimidinecarboxylic acid with an appropriate reagent such as 4-aminobutyric acid in the presence of a solvent such as acetonitrile, followed by the hydrolysis of the intermediate compound.
The reaction results in the formation of 5-pyrimidinecarboxylic acid, 4-ethyl-2-methyl- (9CI) along with the formation of a ammonium sulfate byproduct.

In conclusion, the synthetic routes of 5-pyrimidinecarboxylic acid, 4-ethyl-2-methyl- (9CI) can be broadly classified into three categories: direct synthesis, indirect synthesis, and semisynthesis.
Direct synthesis is the most common method for the production of this compound, which involves the reaction of 4E)-2-methyl-5-pyrimidinecarboxylic acid with an appropriate reagent.
Indirect synthesis is another method for the production of this compound, which involves the synthesis of the intermediate compound (