The Synthetic Routes of 5-METHYLTETRAHYDROFOLIC ACID DISODIUM SALT

5-Methyl-tetrahydrofolic acid disodium salt, also known as 5-Methylfolate or Methylfolate, is a synthetic derivative of folic acid.
It is commonly used in the chemical industry as an intermediate in the production of various drugs and pharmaceuticals.

One of the most popular synthetic routes for the production of 5-Methyl-tetrahydrofolic acid disodium salt involves the use of folic acid as the starting material.
Folic acid is first reduced to dihydrofolic acid using reducing agents such as sodium borohydride or lithium aluminum hydride.
The dihydrofolic acid is then methylated using methyl iodide to yield 5-methyl-tetrahydrofolic acid.
The final step involves the conversion of 5-methyl-tetrahydrofolic acid into the disodium salt form using sodium hydroxide and sodium carbonate.

Another synthetic route involves the use of 5-formyl-tetrahydrofolic acid as the starting material.
5-Formyl-tetrahydrofolic acid is synthesized by the reaction of formaldehyde with para-aminophenol in the presence of an acid catalyst.
The 5-formyl-tetrahydrofolic acid is then methylated using methyl iodide to yield 5-methyl-tetrahydrofolic acid.
The final step involves the conversion of 5-methyl-tetrahydrofolic acid into the disodium salt form using sodium hydroxide and sodium carbonate, similar to the previous route.

In addition to the above-mentioned routes, there are other synthetic methods available for the production of 5-Methyl-tetrahydrofolic acid disodium salt.
These methods include the use of microbial fermentation, enzymatic hydrolysis, and chemical reduction of folic acid.
However, these methods are less commonly used in the chemical industry due to their lower efficiency and higher cost compared to the above-mentioned routes.

The use of 5-Methyl-tetrahydrofolic acid disodium salt in the chemical industry is mainly focused on the production of pharmaceuticals and drugs.
It is used as an intermediate in the synthesis of drugs such as anticonvulsants, antidepressants, and anti-inflammatory drugs.
It is also used in the production of vitamin supplements and nutritional products.

In conclusion, 5-Methyl-tetrahydrofolic acid disodium salt is an important intermediate in the production of various drugs and pharmaceuticals.
It can be produced by several synthetic routes, including the use of folic acid or 5-formyl-tetrahydrofolic acid as starting materials.
The most commonly used methods involve the reduction of folic acid to dihydrofolic acid followed by methylation, and the use of 5-formyl-tetrahydrofolic acid as starting material and subsequent methylation.
These synthetic methods are widely used in the chemical industry, and the demand for 5-Methyl-tetrahydrofolic acid disodium salt is expected to continue to grow in the future.