The Synthetic Routes of 5-METHOXY-PYRIDINE-3-CARBALDEHYDE

The 5-methoxy-pyridine-3-carbaldehyde, also known as 5-MeO-PYRIDINE-3-CARBALDEHYDE, is an important intermediate in the production of various pharmaceuticals, agrochemicals, and other chemical products.
This compound is synthesized through several different routes in the chemical industry.

One of the most common methods of synthesizing 5-MeO-PYRIDINE-3-CARBALDEHYDE involves the reduction of 5-methoxy-2-nitro-1H-pyridine using a reducing agent such as lithium aluminum hydride (LiAlH4).
The reaction proceeds through the following steps:

• Deprotonation of the 5-methoxy-2-nitro-1H-pyridine using a strong base such as sodium hydroxide, followed by reduction with LiAlH4 to yield 5-methoxy-pyridine-3-carbaldehyde.
  

Another synthetic route to 5-MeO-PYRIDINE-3-CARBALDEHYDE involves the reaction of pyridine-2-carboxaldehyde with 5-methoxy-2-nitroaniline in the presence of a strong acid catalyst such as sulfuric acid.
The reaction proceeds through the following steps:

• Deprotonation of 5-methoxy-2-nitroaniline using a strong acid such as sulfuric acid, followed by nucleophilic substitution with pyridine-2-carboxaldehyde to yield 5-methoxy-pyridine-3-carbaldehyde.
  

A third synthetic route to 5-MeO-PYRIDINE-3-CARBALDEHYDE involves the reaction of 2-nitro-5-methoxy-pyridine with formaldehyde in the presence of a strong acid catalyst such as sulfuric acid.
The reaction proceeds through the following steps:

• Deprotonation of 2-nitro-5-methoxy-pyridine using a strong acid such as sulfuric acid, followed by nucleophilic substitution with formaldehyde to yield 5-methoxy-pyridine-3-carbaldehyde.
  

Once synthesized, 5-MeO-PYRIDINE-3-CARBALDEHYDE can be purified using various methods such as recrystallization, chromatography, and sublimation.
The purified compound is then used as an intermediate in the production of various pharmaceuticals, agrochemicals, and other chemical products.

In conclusion, 5-methoxy-pyridine-3-carbaldehyde is an important intermediate in the chemical industry that is synthesized through several different routes.
These routes include the reduction of 5-methoxy-2-nitro-1H-pyridine using LiAlH4, the reaction of pyridine-2-carboxaldehyde with 5-methoxy-2-nitroaniline in the presence of sulfuric acid, and the reaction of 2-nitro-5-methoxy-pyridine with formaldehyde in the presence of sulfuric acid.
The purified compound is then used as an intermediate in the production of various pharmaceuticals, agrochemicals, and other chemical products.