The Synthetic Routes of 5-Isoquinolinamine,3-chloro-(9CI)

5-Isoquinolinamine, also known as quinoline-5-amine, is an important intermediate in the synthesis of various chemicals, drugs, and other products.
One of the most commonly used synthetic routes for the preparation of 5-isoquinolinamine is the Williamson ether synthesis, which involves the reaction of an alcohol with an alkyl halide in the presence of a base, such as sodium hydroxide, to form an ether and a byproduct, such as water or an alcohol.

Another synthetic route for 5-isoquinolinamine is the reaction of an amine with an aldehyde or ketone in the presence of an acid catalyst, such as sulfuric acid, to form an amine-aldehyde or amine-ketone adduct.
The adduct can then be transformed into 5-isoquinolinamine via a series of steps, such as hydrolysis, reduction, and oxidation.

A variation of the above route, is the reaction of an amine with 3-chloro-1,2-benzisoxazole-5-carboxylic acid, also known as chloramphenicol, to form an amide and an intermediate carboxylate.
The carboxylate can be esterified with an alcohol, such as methanol, to form the corresponding ester, which can then be reduced to form 5-isoquinolinamine.

Another synthetic route for 5-isoquinolinamine is the reaction of an amide with an isocyanate in the presence of a solvent, such as water or an organic solvent, and a catalyst, such as potassium hydroxide or sodium hydroxide, to form an urea and a byproduct, such as water or an organic solvent.
The urea can then be hydrolyzed to form 5-isoquinolinamine.

It is worth noting that, even though these routes have been reported in literature, it's always recommended to check the patent status of the process and the availability of the reagents before starting synthesizing a new compound.
Additionally, it's also important to consider the environmental impact, safety and economical aspects of the process before choosing a synthetic route.