The Synthetic Routes of (5-Chloro-pyrimidin-2-yl)-ethyl-amine

The Synthetic Routes of (5-Chloro-pyrimidin-2-yl)-ethyl-amine: A Comprehensive Overview of the Chemical Industry

Introduction:

(5-Chloro-pyrimidin-2-yl)-ethyl-amine is an important organic compound that finds application in various fields, including pharmaceuticals, agrochemicals, and materials science.
The synthetic routes for this compound have been extensively studied and investigated in the chemical industry.
In this article, we will provide a comprehensive overview of the different synthetic routes for (5-Chloro-pyrimidin-2-yl)-ethyl-amine.

Chemical properties of (5-Chloro-pyrimidin-2-yl)-ethyl-amine:

(5-Chloro-pyrimidin-2-yl)-ethyl-amine is a colorless liquid with a distinctive odor.
It is soluble in water and organic solvents.
The compound exhibits good stability under normal conditions, but it can undergo thermal degradation at high temperatures.
(5-Chloro-pyrimidin-2-yl)-ethyl-amine is a restricted substance and requires proper handling and disposal.

Synthetic routes for (5-Chloro-pyrimidin-2-yl)-ethyl-amine:

There are several synthetic routes for the production of (5-Chloro-pyrimidin-2-yl)-ethyl-amine, each with its own advantages and disadvantages.
The following is an overview of the most commonly used synthetic routes for this compound:

1. Direct nitration of pyrimidine:

This is the most straightforward synthetic route for the production of (5-Chloro-pyrimidin-2-yl)-ethyl-amine.
In this process, pyrimidine is treated with nitric acid to form the corresponding nitro derivative.
The nitro derivative is then hydrolyzed using a strong acid, such as hydrochloric acid, to form the amine.
Finally, the amine is chlorinated using a chlorinating agent, such as chloroform, to form the final product.

Advantages:

• Simple and straightforward process.
  
• Low cost of production.
  

Disadvantages:

• Yields of the final product can be low.
  
• The process generates hazardous waste, including nitric acid and hydrochloric acid.
  

1. Reduction of nitro compound:

In this process, a nitro derivative of (5-Chloro-pyrimidin-2-yl)-ethyl-amine is reduced using a reducing agent, such as hydrogen gas or sodium borohydride, to form the corresponding amine.
The reducing agent is then removed by precipitation or distillation, and the resulting amine is chlorinated using a chlorinating agent, such as chloroform, to form the final product.

Advantages:

• Higher yield of the final product compared to the direct nitration process.
  
• Less hazardous waste generation compared to the direct nitration process.
  

Disadvantages:

• Requires additional steps compared to the direct nitration process.
  
• The reducing agent and chlorinating agent can be expensive.
  

1. Hydrolysis of amidine:

In this process, (5-Chloro-pyrimidin-2-yl)-ethyl-amine is synthesized by reacting ethylamine with chlorine in the presence of a catalyst, such as an acid catalyst or a metal catalyst.
The resulting amidine is then hydrolyzed using a strong acid, such as hydrochloric acid, to form the amine.
Finally, the amine is chlorin