The Synthetic Routes of (5-Chloro-pyrimidin-2-yl)-cyclopropyl-amine

The Synthetic Routes of (5-Chloro-pyrimidin-2-yl)-cyclopropyl-amine: A Comprehensive Overview in the Chemical Industry

Introduction

(5-Chloro-pyrimidin-2-yl)-cyclopropyl-amine is an important organic compound that finds widespread applications in the pharmaceutical, agrochemical, and chemical industries.
The synthetic routes to this compound have been extensively investigated in the scientific literature over the past few decades.
In this article, we will provide a comprehensive overview of the different synthetic routes to (5-Chloro-pyrimidin-2-yl)-cyclopropyl-amine, including the conventional methods as well as the recent advances in synthetic methodologies.

Synthetic Routes to (5-Chloro-pyrimidin-2-yl)-cyclopropyl-amine

Conventional Synthetic Routes

The conventional synthetic routes to (5-Chloro-pyrimidin-2-yl)-cyclopropyl-amine include the following:

1. Hydrochlorination of pyrimidine-5-carbaldehyde: This method involves the conversion of pyrimidine-5-carbaldehyde into (5-chloro-pyrimidin-2-yl)-cyclopropyl-amine through the reaction with sodium hypochlorite.
   
2. Nitration of pyrimidine-5-carbaldehyde: This method involves the conversion of pyrimidine-5-carbaldehyde into (5-chloro-pyrimidin-2-yl)-cyclopropyl-amine through the reaction with nitrating agents such as nitrating acid or nitric acid.
   
3. Chlorination of pyrimidine-5-carbaldehyde: This method involves the conversion of pyrimidine-5-carbaldehyde into (5-chloro-pyrimidin-2-yl)-cyclopropyl-amine through the reaction with chlorinating agents such as bleach (sodium hypochlorite) or thionyl chloride.
   
4. Direct reaction with chlorine: This method involves the direct reaction of chlorine with pyrimidine-5-carbaldehyde to form (5-chloro-pyrimidin-2-yl)-cyclopropyl-amine.
   

Advantages and Limitations of Conventional Synthetic Routes

The conventional synthetic routes to (5-Chloro-pyrimidin-2-yl)-cyclopropyl-amine are well-established and relatively simple.
They are relatively inexpensive and can be easily scaled up for industrial applications.
However, these methods also have some limitations.
For example, some of these methods require the use of hazardous reagents and precursors, and some of them may produce unwanted by-products or side products.
In addition, some of these methods may not be environmentally friendly, and proper disposal of the reaction by-products and waste products is essential.

Recent Advances in Synthetic Methodologies

In recent years, there has been a growing interest in developing new and more efficient synthetic methodologies for the preparation of (5-Chloro-pyrimidin-2-yl)-cyclopropyl-amine.
Some of the recent advances in synthetic methodologies for this compound include the following:

1. Enzymatic synthesis: This method involves the use of enzymes to catalyze the synthesis of (5-Chloro-pyrimidin-2-yl)-cyclopropyl-amine from pyrimidine-5-carbaldehyde.
   This method is environment