The Synthetic Routes of 4-Pyrimidinemethanol, 2-amino-6-methyl- (9CI)

The Synthetic Routes of 4-Pyrimidinemethanol, 2-amino-6-methyl- (9CI) in Chemical Industry

4-Pyrimidinemethanol, 2-amino-6-methyl- (9CI), also known as Amoxicillin, is a widely used antibiotic in the treatment of bacterial infections.
The chemical structure of Amoxicillin belongs to the group of 4-amino-2-oxa-5-azoline-3-carboxylic acids.
The synthesis of this compound has been extensively studied in the chemical industry, and there are several synthetic routes available for its preparation.
In this article, we will discuss some of the most common synthetic routes for the preparation of 4-Pyrimidinemethanol, 2-amino-6-methyl- (9CI) in chemical industry.

1. Routes I and II

Route I involves the reaction of phenylglyoxylate with chloramphenicol to produce N-(2,6-dimethylphenyl)acetamide, which is then sulfonated to produce N-(2,6-dimethylphenyl)sulfamide.
This intermediate is then condensed with para-substituted anilines to produce the 4-pyrimidinemethanol.

Route II involves the condensation of para-substituted anilines with chlorambutol to produce an intermediate, which is then hydroxylated to produce 4-hydroxy-para-substituted anilines.
These intermediates are then sulfonated to produce the 4-pyrimidinemethanol.

2. Route III

Route III involves the reaction of para-substituted anilines with phenylglyoxylate to produce the corresponding N-(2,6-dimethylphenyl)acetamides.
These intermediates are then sulfonated to produce the 4-pyrimidinemethanol.

3. Route IV

Route IV involves the synthesis of the intermediate 4-nitro-2-oxa-5-azoline-3-carboxylic acid, which is then reduced to produce the 4-pyrimidinemethanol.
This route also involves the use of several chemical reactions such as nitration, reduction, and condensation.

4. Route V

Route V involves the synthesis of the 4-pyrimidinemethanol by a two-step process.
In the first step, the intermediate 3-amino-2-oxa-5-azoline-4-carboxylic acid is synthesized, which is then hydrolyzed to produce the 4-pyrimidinemethanol.

In conclusion, there are several synthetic routes available for the preparation of 4-Pyrimidinemethanol, 2-amino-6-methyl- (9CI) in chemical industry.
These routes involve the use of various chemical reactions such as condensation, hydrolysis, nitration, reduction, and sulfonation.
The choice of route depends on the availability and cost of raw materials, as well as the desired yield and purity of the product.