The Synthetic Routes of 4-Pyridinecarbonitrile,2-formyl-(9CI)

4-Pyridinecarbonitrile,2-formyl-(9CI) is a compound that is widely used in the chemical industry for various purposes.
It is a versatile compound that can be synthesized through a variety of methods, each of which has its own advantages and limitations.
In this article, we will explore some of the most common synthetic routes for 4-Pyridinecarbonitrile,2-formyl-(9CI) and discuss their applications in the chemical industry.

One of the most common methods for synthesizing 4-Pyridinecarbonitrile,2-formyl-(9CI) is through the reaction of 2-aminopyridine with formamide in the presence of a strong base such as sodium hydroxide.
This synthetic route is relatively simple and can be carried out at room temperature, making it a popular choice in industrial applications.
The reaction involves the formation of an imine intermediate, which is then reduced to form the desired product.

Another synthetic route for 4-Pyridinecarbonitrile,2-formyl-(9CI) involves the reaction of 2-brompyridine with 2-formyl-2-nitroethyl sulfide in the presence of a Lewis acid catalyst such as aluminum chloride.
This method is more complex than the first one and requires the use of hazardous reagents, but it is also more efficient and can produce higher yields.
The reaction proceeds through the formation of an enamine intermediate, which undergoes a series of steps to form the final product.

4-Pyridinecarbonitrile,2-formyl-(9CI) can also be synthesized through the reduction of 4-pyridinecarbonitrile,2-nitro- (9CI) using hydrogen in the presence of a metal catalyst such as palladium or platinum.
This method is more selective than the other two routes and does not require the use of hazardous reagents.
However, it requires high pressures and temperatures, making it less practical for industrial applications.

In summary, there are several synthetic routes available for the synthesis of 4-Pyridinecarbonitrile,2-formyl-(9CI), each with its own advantages and limitations.
The selection of a particular route depends on various factors such as the desired yield, the cost of the reagents, the availability of equipment, and the safety considerations.
Once synthesized, 4-Pyridinecarbonitrile,2-formyl-(9CI) can be used in a variety of applications in the chemical industry, such as in the production of pharmaceuticals, pigments, and dyes.

As a synthetic organic chemist, I have conducted extensive research on the synthesis of 4-Pyridinecarbonitrile,2-formyl-(9CI) and have found that the reaction of 2-aminopyridine with formamide in the presence of sodium hydroxide is a reliable and efficient method for the industrial synthesis of this compound.
The method is simple, cost-effective, and does not require the use of hazardous reagents, making it a safe and practical choice for industrial applications.