The Synthetic Routes of 4-PYRIDAZINEMETHANAMINE

4-Pyridazinemethanamine is an important organic compound that finds applications in various fields of the chemical industry.
Its synthetic routes are not only varied but also versatile, making it a synthetic target of great interest.
This article provides an overview of the various synthetic routes to 4-pyridazinemethanamine, including the traditional and modern methods employed in its synthesis.

The traditional synthetic routes

The traditional synthetic routes to 4-pyridazinemethanamine include the following:

The R.
P.
way

The R.
P.
way involves the reduction of 4-nitrophenylacetamide to form 4-nitrophenylacetaldehyde, which is then reduced further to form 4-nitrophenylactic acid.
The acid is then converted to 4-pyridazinemethanamine through the following steps:

1. Hydrolysis of the 4-nitrophenylactic acid to form 4-nitrophenylacetic acid
2. Oxidation of the 4-nitrophenylacetic acid to form 4-nitrophenylazetidine-3-one
3. Reduction of the 4-nitrophenylazetidine-3-one to form 4-pyridazinemethanamine

The H.
W.
way

The H.
W.
way involves the reduction of 4-nitrophenylazo-2,4-dinitrobenzene to form 4-nitrophenylacetic acid.
The acid is then converted to 4-pyridazinemethanamine through the following steps:

1. Hydrolysis of the 4-nitrophenylacetic acid to form 4-nitrophenylacetic acid
2. Reduction of the 4-nitrophenylacetic acid to form 4-pyridazinemethanamine

The Mannich reaction

The Mannich reaction involves the condensation of formaldehyde, acetaldehyde, and ammonia to form 4-pyridazinemethanamine.
The reaction is carried out in the presence of a base, such as sodium hydroxide, and is followed by hydrolysis of the resulting intermediate to form 4-pyridazinemethanamine.

The modern synthetic routes

The modern synthetic routes to 4-pyridazinemethanamine include the following:

The palladium-catalyzed cross-coupling reaction

The palladium-catalyzed cross-coupling reaction involves the reaction of an aryl halide with an arylboronic acid in the presence of a palladium catalyst.
The reaction produces 4-pyridazinemethanamine, which can be further purified and used as desired.

The Sonogashira reaction

The Sonogashira reaction involves the condensation of an aryl halide with a phenyl acetate in the presence of a palladium catalyst.
The reaction produces 4-pyridazinemethanamine, which can be further purified and used as desired.

The Stille reaction

The Stille reaction involves the condensation of an aryl halide with a phenyl dichloride in the presence of a palladium catalyst.
The reaction produces 4-pyridazinemethanamine, which can be further purified and used as desired.

Advantages of modern synthetic routes

The modern synthetic routes to 4-pyridazinemethanamine offer several advantages over the traditional methods.
Firstly, they are more efficient, as they allow for the synthesis of 4-pyridazinemethanamine in a shorter period of time.
Secondly