The Synthetic Routes of 4-(prop-1-ynyl)pyrimidin-2-amine

4-(prop-1-ynyl)pyrimidin-2-amine is an important organic compound that is widely used in various applications in the chemical industry.
It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other chemical products.
The synthesis of 4-(prop-1-ynyl)pyrimidin-2-amine can be achieved through several different synthetic routes, each with its own advantages and disadvantages.

One of the most common synthetic routes for the synthesis of 4-(prop-1-ynyl)pyrimidin-2-amine is the Leuckart-Wallach reaction.
This reaction involves the reaction of 2-chloroacetamide with prop-1-ynal in the presence of a strong acid catalyst, such as sulfuric acid or phosphoric acid.
The reaction produces 4-(prop-1-ynyl)pyrimidin-2-amine, which can be further purified and used as an intermediate in downstream synthetic reactions.

Another synthetic route for the synthesis of 4-(prop-1-ynyl)pyrimidin-2-amine involves the use of the Ullmann reaction.
This reaction involves the reaction of an amine, such as pipinic acid, with an aldehyde, such as acetaldehyde, in the presence of a heterogeneous catalyst, such as Raney nickel.
The reaction produces 4-(prop-1-ynyl)pyrimidin-2-amine, which can be further purified and used as an intermediate in downstream synthetic reactions.

A third synthetic route for the synthesis of 4-(prop-1-ynyl)pyrimidin-2-amine involves the use of the Hydroxyllithium-mediated reaction.
This reaction involves the reaction of lithium cyanide with prop-1-ynal in the presence of a hydroxyllithium reagent, such as lithium tri-tert-butoxyaluminum hydride.
The reaction produces 4-(prop-1-ynyl)pyrimidin-2-amine, which can be further purified and used as an intermediate in downstream synthetic reactions.

The choice of synthetic route for the synthesis of 4-(prop-1-ynyl)pyrimidin-2-amine will depend on a variety of factors, such as the availability and cost of starting materials, the desired yield and purity of the final product, and the desired final usage of the product.
In general, the Leuckart-Wallach reaction is a commonly used synthetic route due to its simplicity and high yield.
However, the other synthetic routes, such as the Ullmann reaction and the Hydroxyllithium-mediated reaction, can also be effective for the synthesis of 4-(prop-1-ynyl)pyrimidin-2-amine, depending on the specific requirements of the synthetic process.