The Synthetic Routes of 4-phenyl-2-(trifluoroMethyl)pyriMidine

4-phenyl-2-(trifluoroMethyl)pyriMidine is a synthetic compound that is commonly used in the chemical industry.
It is a derivative of pyridine, and is characterized by its yellow crystalline solid appearance, strong smell of garlic and its ability to dissolve in water and many organic solvents.
This compound is widely used in various applications such as in the production of agrochemicals, pharmaceuticals, and other specialty chemicals.

There are several synthetic routes that can be used to produce 4-phenyl-2-(trifluoroMethyl)pyriMidine, each with its own advantages and disadvantages.
The most commonly used methods include the following:

1. The Luche Test

The Luche test is a simple and quick method for the preparation of 4-phenyl-2-(trifluoroMethyl)pyriMidine.
This method involves the reaction of phenyl-trifluoroacetamide with dimethylamine in the presence of a solvent such as ether or benzene.
The reaction produces 4-phenyl-2-(trifluoroMethyl)pyriMidine, which can be isolated by filtration and then recrystallized.

2. The Armstrong Reduction

The Armstrong reduction is a method for the reduction of 2-nitro-4-phenyl-butyronitrile to 2-amino-4-phenyl-butyronitrile, which can then be converted to 4-phenyl-2-(trifluoroMethyl)pyriMidine by reaction with trifluoroacetic anhydride in the presence of a solvent such as pyridine or dichloromethane.

3. The Blanc-Kelly Chemistry

The Blanc-Kelly chemistry is another synthetic method for the production of 4-phenyl-2-(trifluoroMethyl)pyriMidine.
This method involves the reaction of 4-chloropyrimidine with 2,4,6-trichloroaniline in the presence of a solvent such as acetonitrile or chloroform.
The reaction produces 4-phenyl-2-(trifluoroMethyl)pyriMidine, which can be isolated by filtration and then recrystallized.

4. The Hydrolysis of N-[2-(Trifluoromethyl)Pyridine]-4-nitrophenyl Amide

The hydrolysis of N-[2-(Trifluoromethyl)Pyridine]-4-nitrophenyl amide is a synthetic method that involves the reaction of N-[2-(trifluoromethyl)pyridine]-4-nitrophenyl amide with water in the presence of a solvent such as ethanol or methanol.
The reaction produces 4-phenyl-2-(trifluoroMethyl)pyriMidine, which can be isolated by filtration and then recrystallized.

In conclusion, there are several synthetic routes that can be used to produce 4-phenyl-2-(trifluoroMethyl)pyriMidine.
Each method has its own advantages and disadvantages, and the choice of method depends on factors such as cost, availability of reagents, and the desired yield of the product.
Regardless of the method used, 4-phenyl-2-(trifluoroMethyl)pyriMidine is a useful compound in the chemical industry that can be used in a variety of applications.