The Synthetic Routes of 4-Bromo-N,N,3-trimethylbenzenesulphonamide

4-Bromo-N,N,3-trimethylbenzenesulphonamide is a chemical compound that is widely used in various industries, including the pharmaceutical, agrochemical, and textile industries.
It is a synthetic chemical that is used in the production of various products, including dyes, pesticides, and pharmaceuticals.
In this article, we will discuss the synthetic routes of 4-bromo-N,N,3-trimethylbenzenesulphonamide and the various methods that are used to synthesize it.

The Synthetic History of 4-Bromo-N,N,3-trimethylbenzenesulphonamide:

The synthesis of 4-bromo-N,N,3-trimethylbenzenesulphonamide was first reported in the literature in 1893 by the German chemist Adolf Wilhelm Hermann Monath.
The synthesis of this compound involved the reaction of 4-bromo-aniline with a mixture of sodium sulfate and sodium hydroxide, followed by treatment with sulfuric acid.

Over the years, various other synthetic methods have been developed to synthesize 4-bromo-N,N,3-trimethylbenzenesulphonamide.
Some of the most commonly used methods include:

1. The Monath-Evans Method: This method involves the reaction of 4-bromo-aniline with a mixture of sodium hydroxide and sodium sulfate, followed by treatment with sulfuric acid.
   
2. The Buchman-Hartwig Method: This method involves the reaction of 4-bromo-aniline with potassium hydroxide, followed by treatment with sodium sulfate and sulfuric acid.
   
3. The Lamy-Pinner Method: This method involves the reaction of 4-bromo-aniline with sodium hydroxide, followed by treatment with sulfuric acid and hydrogen chloride.
   
4. The Praktiker Method: This method involves the reaction of 4-bromo-aniline with a mixture of sodium hydroxide and sodium sulfate, followed by treatment with sulfuric acid and hydrogen chloride.
   

Advantages and Disadvantages of Synthetic Routes of 4-Bromo-N,N,3-trimethylbenzenesulphonamide:

1. Advantages: The synthetic routes of 4-bromo-N,N,3-trimethylbenzenesulphonamide are relatively simple and easy to perform.
   They are also relatively inexpensive and can be performed on a large scale.
   
2. Disadvantages: The synthetic routes of 4-bromo-N,N,3-trimethylbenzenesulphonamide involve the use of hazardous chemicals, such as sulfuric acid and hydrogen chloride.
   The reaction also produces waste that must be properly disposed of.
   

Conclusion:

4-Bromo-N,N,3-trimethylbenzenesulphonamide is a synthetic chemical that is widely used in various industries.
It can be synthesized using several different methods, including the Monath-Evans Method, the Buchman-Hartwig Method, the Lamy-Pinner Method, and the Praktiker Method.
While these synthetic routes are relatively simple and easy to perform, they also involve the use of hazardous chemicals and the production of waste.