The Synthetic Routes of (4-AMINO-PYRIDIN-3-YL)-METHANOL

Introduction

In the chemical industry, there are many different methods for synthesizing compounds.
One common method is the synthesis of (4-AMINO-PYRIDIN-3-YL)-METHANOL, which is widely used in various applications such as in the production of pharmaceuticals, dyes, and agricultural chemicals.
In this article, we will discuss the various synthetic routes that are commonly used to synthesize (4-AMINO-PYRIDIN-3-YL)-METHANOL.

Synthesis of (4-AMINO-PYRIDIN-3-YL)-METHANOL via the Mannich Reaction

One of the most common methods for synthesizing (4-AMINO-PYRIDIN-3-YL)-METHANOL is through the Mannich reaction.
This reaction involves the condensation of formaldehyde, ammonia, and a primary or secondary alkyl or aryl halide in the presence of a catalyst such as cobalt or copper.
The resulting product is then hydrolyzed to form (4-AMINO-PYRIDIN-3-YL)-METHANOL.

Synthesis of (4-AMINO-PYRIDIN-3-YL)-METHANOL via the Barbituric Acid Synthesis

Another method for synthesizing (4-AMINO-PYRIDIN-3-YL)-METHANOL is through the Barbituric acid synthesis, which involves the reaction of ammonia and a solution of sodium sulfate in the presence of a primary or secondary amine and an acid catalyst such as hydrochloric acid.
The resulting product is then hydrolyzed to form (4-AMINO-PYRIDIN-3-YL)-METHANOL.

Synthesis of (4-AMINO-PYRIDIN-3-YL)-METHANOL via the Gomberg-Bommerhouwer Distillation

(4-AMINO-PYRIDIN-3-YL)-METHANOL can also be synthesized through the Gomberg-Bommerhouwer distillation, which involves the reduction of 2,4-dichloro-5-nitropyridine using lithium aluminum hydride (LiAlH4) in the presence of an amine such as triethylamine.
The resulting product is then hydrolyzed to form (4-AMINO-PYRIDIN-3-YL)-METHANOL.

Advantages and Limitations of Synthetic Routes

Each of the synthetic routes for synthesizing (4-AMINO-PYRIDIN-3-YL)-METHANOL has its own advantages and limitations.
For example, the Mannich reaction is simple and efficient, but it requires the use of a catalyst and can generate toxic byproducts.
On the other hand, the Gomberg-Bommerhouwer distillation is more environmentally friendly as it does not generate toxic byproducts, but it requires specialized equipment and is more complex.

Applications of (4-AMINO-PYRIDIN-3-YL)-METHANOL

(4-AMINO-PYRIDIN-3-YL)-METHANOL is widely used in a variety of applications, including the production of pharmaceuticals, dyes, and agricultural chemicals.
For example, it is used as an intermediate in the production of antihypertensive drugs and antidepressants.
It is also used as a building block for the synthesis of other compounds, such as dyes, pigments, and plastics.

Conclusion

In conclusion, (4-AMINO-PYRIDIN-3-YL)-METHANOL is a versatile compound with a wide range of applications in the chemical industry.
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