The Synthetic Routes of 4-Amino-2-methylquinoline

4-Amino-2-methylquinoline is an important chemical compound used in various industrial applications.
It is commonly used in the production of pharmaceuticals, pigments, dyes, and other chemical products.
The synthetic routes for 4-Amino-2-methylquinoline can vary depending on the desired yield and the availability of starting materials.
In this article, we will discuss some of the most commonly used synthetic routes for this compound.

1. Ammonolysis of 2-Methylquinoline:
   One of the most common methods for synthesizing 4-Amino-2-methylquinoline involves the use of ammonolysis.
   This involves treating 2-methylquinoline with ammonia in the presence of a solvent such as hydrochloric acid or sulfuric acid.
   The reaction produces 4-amino-2-methylquinoline as a product.
   
2. Reduction of N-Methyl-4-nitro-2-quinoline:
   Another synthetic route for 4-Amino-2-methylquinoline involves the reduction of N-methyl-4-nitro-2-quinoline.
   This involves treating N-methyl-4-nitro-2-quinoline with a reducing agent such as sodium borohydride in a solvent such as methanol or ethanol.
   The reaction results in the reduction of the nitro group to an amino group, yielding 4-Amino-2-methylquinoline.
   
3. Decarboxylation of 4-Methyl-2-[[4-[(methylamino)methyl]-2- oxo-1,3-oxazolidin-3-yl]methyl]-1H-quinolin-2-one:
   This method involves the use of a decarboxylation reaction to synthesize 4-Amino-2-methylquinoline.
   The reaction involves treating 4-methyl-2-[[4-[(methylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl]methyl]-1H-quinolin-2-one with an acid such as hydrochloric acid or sulfuric acid in the presence of a solvent such as toluene or xylene.
   The decarboxylation reaction results in the formation of 4-Amino-2-methylquinoline.
   
4. Reaction with Chloramine T:
   Another synthetic route for 4-Amino-2-methylquinoline involves the use of chloramine T as a reagent.
   This involves treating 2-methylquinoline with chloramine T in the presence of a solvent such as acetone or ether.
   The reaction results in the formation of 4-Amino-2-methylquinoline.
   

Overall, the synthetic routes for 4-Amino-2-methylquinoline are numerous and varied.
The choice of synthetic route will depend on various factors such as the desired yield, the availability of starting materials, and the desired end product.
Regardless of the synthetic route used, 4-Amino-2-methylquinoline is an important compound with a wide range of industrial applications.
It is commonly used in the production of pharmaceuticals, pigments, dyes, and other chemical products.