The Synthetic Routes of 4,6-BIS(DIFLUOROMETHOXY)-2-(METHYLTHIO)PYRIMIDINE

4,6-BIS(DIFLUOROMETHOXY)-2-(METHYLTHIO)PYRIMIDINE is an organic compound that has a wide range of applications in the chemical industry.
It is a synthetic chemical that is used as an intermediate in the production of various pharmaceuticals, agrochemicals, and other chemical products.

The synthetic routes to 4,6-BIS(DIFLUOROMETHOXY)-2-(METHYLTHIO)PYRIMIDINE can be broadly classified into two categories: direct synthesis and indirect synthesis.

Direct Synthesis:

The direct synthesis of 4,6-BIS(DIFLUOROMETHOXY)-2-(METHYLTHIO)PYRIMIDINE involves the reaction of 4,6-difluoromethoxy-2-nitrobenzaldehyde with a suitable methylthio precursor.
One of the most common methods for the synthesis of 4,6-difluoromethoxy-2-nitrobenzaldehyde is the nitration of 4,6-difluoromethoxy-2-aminobenzene, which is then treated with sodium hydroxide to form the corresponding nitro compound.

The methylthio precursor can be synthesized using various methods, such as the reaction of methyl iodide with sodium hydrosulfide or the reaction of methyl chloride with hydrogen sulfide.
The reaction between the methylthio precursor and 4,6-difluoromethoxy-2-nitrobenzaldehyde is typically carried out in the presence of a solvent, such as DMF or DMA, and a suitable base, such as sodium hydroxide or potassium hydroxide.
The reaction mixture is then typically subjected to conditions that promote the formation of the desired product, such as heating or the addition of a catalyst, such as pyridine.

Indirect Synthesis:

The indirect synthesis of 4,6-BIS(DIFLUOROMETHOXY)-2-(METHYLTHIO)PYRIMIDINE involves the synthesis of a precursor compound that can be converted into the desired product through a series of chemical reactions.
One such precursor is 4,6-difluoromethoxy-2-(methylthiophenyl)oxazole, which can be synthesized by the reaction of 4,6-difluoromethoxy-2-nitrobenzene with methyl iodide in the presence of a base, such as sodium hydroxide.
The resulting oxazole can then be treated with a reducing agent, such as lithium aluminum hydride, to convert it into the corresponding amine.

The amine can then be converted into the desired product through a series of chemical reactions, such as the reaction with an appropriate halogenating agent, the reaction with a sulfating agent, and the reaction with a reducing agent.
The specific conditions and reagents used in these reactions will depend on the particular synthesis route being used.

Purification and Separation:

Once the desired product has been synthesized, it typically requires purification and separation from any unwanted byproducts.
This can be achieved through a variety of methods, such as crystallization, chromatography, and distillation.
The choice of purification method will depend on the particular synthesis route being used and the nature of the resulting product.

Use in Chemical Industry:

4,6-BIS(DIFLUOROMETHOXY)-2-(METHYLTHIO)PYRIMIDINE is used as an intermediate in the production of various pharmaceuticals, agrochemicals, and other chemical products.