The Synthetic Routes of 4,5-Dihydro-6-methyl-3(2H)-pyridazinone

4,5-Dihydro-6-methyl-3(2H)-pyrazine is an important organic compound that is widely used in various industrial applications.
It is a synthetic chemical intermediate that can be derived from several natural sources or synthesized through various chemical routes.
In this article, we will discuss the synthetic routes of 4,5-dihydro-6-methyl-3(2H)-pyrazine, which are commonly used in the chemical industry.

1. Direct Hydrolysis of N-Benzyl-3-methyl-6-vinyl-2,4-dioxopyridazin-5-amine

N-Benzyl-3-methyl-6-vinyl-2,4-dioxopyridazin-5-amine is a readily available precursor to 4,5-dihydro-6-methyl-3(2H)-pyrazine.
The direct hydrolysis of N-Benzyl-3-methyl-6-vinyl-2,4-dioxopyridazin-5-amine in basic conditions, such as with sodium hydroxide, yields 4,5-dihydro-6-methyl-3(2H)-pyrazine.

2. Reduction of N-Benzyl-6-methyl-pyrazine-2-carboxaldehyde

N-Benzyl-6-methyl-pyrazine-2-carboxaldehyde can be reduced to 4,5-dihydro-6-methyl-3(2H)-pyrazine using various reducing agents such as lithium aluminum hydride (LiAlH4) or hydrogen in the presence of a catalyst, such as palladium on barium sulfate.

3. Decarboxylation of 3-methyl-2H-pyrazine-6-carboxylic acid

3-Methyl-2H-pyrazine-6-carboxylic acid can be decarboxylated using various decarboxylation reagents such as sodium hydroxide or potassium hydroxide to yield 4,5-dihydro-6-methyl-3(2H)-pyrazine.

4. Reaction of 6-methyl-pyrazine-2,4-dioxine with Hydrogen Peroxide

6-Methyl-pyrazine-2,4-dioxine can be treated with hydrogen peroxide in the presence of a suitable catalyst, such as iron(III) chloride, to yield 4,5-dihydro-6-methyl-3(2H)-pyrazine.

5. Dealkylation of N-(4-Methoxyphenyl)Pyrazine-2-carboxamide

N-(4-Methoxyphenyl)Pyrazine-2-carboxamide can be dealkylated using various dealkylation reagents such as hydrogen chloride or thionyl chloride in the presence of a catalyst, such as ferric chloride, to yield 4,5-dihydro-6-methyl-3(2H)-pyrazine.

6. Dehydrogenation of N-Methyl-6-vinyl-2,4-dioxopyrazine-3-amine

N-Methyl-6-vinyl-2,4-dioxopyrazine-3-amine can be dehydrogenated using various dehydrogenation reagents such as heat, sodium or lithium in the presence of a catalyst, such as copper, to yield 4,5-dihydro-6-methyl-3(2H)-pyrazine.