The Synthetic Routes of 3(2H)-Pyridazinone,5-amino-(6CI,7CI,9CI)

The Synthetic Routes of 3(2H)-Pyridazinone,5-amino-(6CI,7CI,9CI)

In the chemical industry, the synthesis of useful organic compounds is of great importance.
One such compound is 3(2H)-Pyridazinone,5-amino-(6CI,7CI,9CI), which has a wide range of applications in the pharmaceutical and agrochemical industries.
This compound can be synthesized through various synthetic routes, some of which are more efficient and cost-effective than others.
In this article, we will discuss the different synthetic routes that are currently being used to synthesize 3(2H)-Pyridazinone,5-amino-(6CI,7CI,9CI).

Synthetic Route 1: via 2-Chloropyridine

One of the most commonly used synthetic routes to synthesize 3(2H)-Pyridazinone,5-amino-(6CI,7CI,9CI) is via 2-chloropyridine.
This route involves the synthesis of 2-chloropyridine, followed by its nitration with nitric acid to form 2-nitro-4-chloropyridine.
The subsequent reaction of this compound with ammonia results in the formation of 3(2H)-Pyridazinone,5-amino-(6CI,7CI,9CI).
This route is relatively simple and inexpensive, but it is also quite polluting, as it involves the use of hazardous chemicals such as nitric acid.

Synthetic Route 2: via 2-Aminopyridine

Another common synthetic route to synthesize 3(2H)-Pyridazinone,5-amino-(6CI,7CI,9CI) is via 2-amino-3-chloropyridine.
This route involves the synthesis of 2-amino-3-chloropyridine, followed by its reduction with lithium aluminum hydride (LiAlH4) to form 2-amino-5-chloropyridine.
The subsequent reaction of this compound with sodium azide (NaN3) results in the formation of 3(2H)-Pyridazinone,5-amino-(6CI,7CI,9CI).
This route is less polluting than the previous route, as it does not involve the use of hazardous chemicals such as nitric acid.

Synthetic Route 3: via 2-Aminopyridine and Nitration

A third synthetic route to synthesize 3(2H)-Pyridazinone,5-amino-(6CI,7CI,9CI) is via 2-amino-5-chloropyridine and nitration with nitric acid.
This route involves the synthesis of 2-amino-5-chloropyridine, followed by its nitration with nitric acid to form 2-nitro-5-chloropyridine.
The subsequent reaction of this compound with sodium azide results in the formation of 3(2H)-Pyridazinone,5-amino-(6CI,7CI,9CI).
This route is similar to the previous route in terms of its efficiency and cost-effectiveness, and it is also less polluting than the first route.

In conclusion, the synthetic routes to synthesize 3(2H)-Pyridazinone,5-amino-(6CI,7CI,9CI) are varied and can be tailored to suit specific requirements.
The most commonly used routes are via 2-chloropyridine, 2-amino-3-chloropyridine, and 2-amino-5-chloropyridine and nitration.
While each route has its own advantages and disadvantages, they