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The Synthetic Routes of 3-Thiopheneacetonitrile

 Last Update: 2023-05-17
 Source: Internet
 Author: User

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3-Thiopheneacetonitrile (3-TAN) is an important building block in the synthesis of various organic compounds.
It finds applications in the manufacturing of pharmaceuticals, agrochemicals, and other specialty chemicals.
The synthetic routes for 3-TAN have evolved over the years, and various methods have been developed to synthesize this compound.

The earliest method for the synthesis of 3-TAN involved the reduction of 3-nitrothiophene-2-carboxaldehyde using lithium aluminum hydride (LiAlH4) in a polar solvent such as dimethylformamide (DMF).
This method suffered from several drawbacks, including the requiremen

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