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The synthesis of 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, compd.
with 3-pyridinecarboxylic acid (1:1) is an important synthetic route in the chemical industry.
This compound, commonly referred to as a heterocyclic compound, plays a vital role in the production of various chemicals, drugs, and other products.
The synthesis of 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, compd.
with 3-pyridinecarboxylic acid (1:1) can be achieved through various synthetic routes.
The most common method involves the reaction of 3-Quinolinecarboxylic acid with 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)hydroxylamine, which is then followed by the condensation with 3-pyridinecarboxylic acid.
The first step in the synthesis of 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, compd.
with 3-pyridinecarboxylic acid (1:1) involves the preparation of 3-Quinolinecarboxylic acid.
This can be achieved through various methods, such as the nitration of quinoline with nitric acid and the subsequent reduction with hydrogen in the presence of a reducing agent, such as palladium on barium sulfate.
In the next step, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)hydroxylamine is synthesized through the reaction of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-fluoro-1,4-dihydroquinoline-3-carboxylate, which is prepared by the reaction of 1,4-dihydroquinoline with 6-fluoro-1,4-dihydro-4-oxo-7-fluoro-1,4-dihydroquinoline-3-carboxylic acid, with piperazine in the presence of a strong acid catalyst, such as sulfuric acid.
Once 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)hydroxylamine is prepared, it can be condensed with 3-Quinolinecarboxylic acid to produce 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl), compd.
with 3-pyridinecarboxylic acid (1:1).
This reaction can be carried out in the presence of a solvent, such as ethyl ether, and a base, such as sodium hydroxide.
The synthesis of 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, compd.
with 3-pyridinecarboxylic acid (1:1) can also be achieved through other synthetic routes, such as the reaction of 3-Quinolinecarboxylic acid with 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-
