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3-Pyridinecarbonitrile,6-methoxy-2-methyl-(9CI) is a molecule that is commonly used in the chemical industry for various applications.
The synthesis of this molecule can be achieved through several routes, both natural and synthetic.
In this article, we will discuss some of the most common synthetic routes to obtain 3-Pyridinecarbonitrile,6-methoxy-2-methyl-(9CI).
- The Hydrogenation of N-Methyl-6-methoxy-2-methylpyridine-3-carboxamide:
One of the most common synthetic routes to obtain 3-Pyridinecarbonitrile,6-methoxy-2-methyl-(9CI) is through the hydrogenation of N-methyl-6-methoxy-2-methylpyridine-3-carboxamide.
This reaction requires the use of hydrogen gas and a catalyst, such as palladium on barium sulfate, to reduce the nitrogen group in the starting material to an amine.
The amine can then be hydrolyzed to produce the desired carbonitrile. - The Reduction of N-Methyl-6-chloro-2-methylpyridine-3-carboxamide:
Another synthetic route to obtain 3-Pyridinecarbonitrile,6-methoxy-2-methyl-(9CI) is through the reduction of N-methyl-6-chloro-2-methylpyridine-3-carboxamide.
This reaction can be carried out using various reducing agents, such as lithium aluminum hydride or hydrogen in the presence of a catalyst, such as palladium on barium sulfate.
The reduction of the carboxamide group in the starting material produces the desired carbonitrile. - The Reaction of Pyridine-3-carboxaldehyde with Methyl Iodide:
3-Pyridinecarbonitrile,6-methoxy-2-methyl-(9CI) can also be synthesized by the reaction of pyridine-3-carboxaldehyde with methyl iodide in the presence of a Lewis acid catalyst, such as aluminum chloride.
This reaction produces the desired carbonitrile, which can then be hydrolyzed to produce the final product. - The Decarboxylation of 3-Pyridinecarbonitrile-6-methoxy-2-methyl-N-methylcarboxamide:
Another synthetic route to obtain 3-Pyridinecarbonitrile,6-methoxy-2-methyl-(9CI) is through the decarboxylation of 3-Pyridinecarbonitrile-6-methoxy-2-methyl-N-methylcarboxamide.
This reaction can be carried out using various decarboxylating agents, such as hydrochloric acid or sodium hydroxide, to remove the carboxylic acid group from the starting material.
The resulting product is the desired carbonitrile.
In conclusion, there are several synthetic routes to obtain 3-Pyridinecarbonitrile,6-methoxy-2-methyl-(9CI) in the chemical industry.
These routes involve various chemical reactions and can be adapted to suit different industrial applications.
The selection of a particular route depends on factors such as the cost of raw materials, the desired purity of the final product, and the scale of production.